不同胃黏膜疾病胃蛋白酶原C组织原位表达与胃蛋白酶原血清学检测水平的比较
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李红梅, 宁佩芳, 袁 媛
胃蛋白酶原C;胃蛋白酶原A;表达;血清学;胃癌,李红梅,宁佩芳,袁媛,通讯作者:,Insituexpressionandser
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李红梅, 宁佩芳, 袁媛, 中国医科大学附属第一医院肿瘤研究所第三研究室 辽宁省沈阳市 110001
国家“十五”科技攻关项目, No.2004BA703B04-02
国家自然科学基金资助项目, No.30171054
通讯作者: 袁媛, 110001, 辽宁省沈阳市, 中国医科大学第一临床医院肿瘤研究所第三研究室. yyuan@mail.cmu.edu.cn
电话: 024-2325666-6153
收稿日期: 2005-09-28 接受日期: 2005-09-30
In situ expression and serum level of pepsinogen C in different gastric mucosa diseases
Hong-Mei Li, Pei-Fang Ning, Yuan Yuan
Hong-Mei Li, Pei-Fang Ning, Yuan Yuan, the Third Department of Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Supported by the National Key Technology Research and Development Program of China during the 10th Five-Year Plan Period, No.2004BA703B04-02, and the National Natural Science Foundation of China, No.30171054
Correspondence to: Dr. Yuan Yuan, the Third Department of Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yyuan@mail.cmu.edu.cn
Received: 2005-09-28 Accepted: 2005-09-30
Abstract
AIM: To explore the matching degree of in situ expression and serum level of pepsinogen C (PGC) in different gastric mucosal biopsies, and to evaluate its value in the diagnosis of gastric cancer.
METHODS: A total of 129 gastric mucosa biopsies and its corresponding serum specimens were collected from patients with superficial gastritis (n = 30), gastric ulcer or erosion (n = 35), atrophic gastritis (29), and gastric cancer (n = 35). The expression of PGC in the gastric mucosa was detected by immunohistochemistry, and the concentration of serum pepsinogen A (sPGA) and pepsinogen C (sPGC) were determined by enzyme linked immunosorbent assay (ELISA).
RESULTS: The positive rate of PGC antigen expression decreased in the tissues of superficial gastritis (100%), gastric ulcer or erosion (80.00%), atrophic gastritis (34 ......
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