全直肠系膜切除术直肠系膜CD44v6检测47例
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宋 哲, 田素礼
CD44v6;直肠系膜;SP免疫组化,宋哲,田素礼,通讯作者:,DetectionofCD44v6inmesorectumfromtotalmesor
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宋哲, 田素礼, 哈尔滨医科大学附属第二医院普外三科 黑龙江省哈尔滨市 150086
通讯作者: 田素礼, 150086, 黑龙江省哈尔滨市学府路246号, 哈尔滨医科大学附属第二医院普外三科. dr_tiansuli@163.com
电话: 0451-86605575
收稿日期: 2005-09-10 接受日期: 2005-09-30
Detection of CD44v6 in mesorectum from total mesorectal excision: an analysis of 47 cases
Zhe Song, Su-Li Tian
Zhe Song, Su-Li Tian, the Third Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Correspondence to: Dr. Su-Li Tian, the Third Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150086, Heilongjiang Province, China. dr_tiansuli@163.com
Received: 2005-09-10 Accepted: 2005-09-30
Abstract
AIM: To detect the expression of CD44 splice variant v6 (CD44v6) in the tissues of rectal cancer and mesorectum, and to prove the scientific nature of the total mesorectal excision for rectal cancer on the basis of molecular level.
METHODS: CD44v6 protein was detected by SP immunohistochemical method in the tissues of rectal cancer, mesorectum (2 cm distal from the tumor), and distal mesorectal margin (5 cm distal from the tumor) from 47 rectal cancer patients received total mesorectal excision.
RESULTS: CD44v6 was highly expressed in the tissues of rectal cancer. The positive rate of CD44v6 expression was significantly different (0/20 vs 15/47, P <0.01) between the normal rectal mucosa and mesorectum (2 cm distal from the tumor), but no significant difference existed between the normal mesorectum and distal mesorectal margin (5 cm distal from the tumor). The positive rate of CD44v6 expression was related with the lymphatic metastasis (metastasisvs non-metastasis: 88.5% vs 61.9%, P <0.05) and clinical stages (Dukes C-D vs A-B: 88.5% vs 61.9%, P <0.05).
CONCLUSION: It is useful to detect the expression of CD44v6 protein in the tissues of rectal cancer for the evaluation of the local apoptotic degree of mesorectum ......
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