潘托拉唑对胃黏膜损伤保护作用及其机制
http://www.100md.com
乐桥良, 张志坚, 林克荣, 王 雯
潘托拉唑;胃黏膜损伤;细胞保护;一氧化氮,乐桥良,张志坚,林克荣,王雯,通讯作者:,Protectiveeffectofpantoprazoleongastri
 |
| 第1页 |
参见附件(880KB，5页)。
乐桥良, 张志坚, 林克荣, 王雯, 南京军区福州总医院消化科 福建省福州市 350025
通讯作者: 乐桥良, 350025, 福建省福州市西二环北路156号, 南京军区福州总医院消化科. leql@sina.com
电话: 0591-87893856
收稿日期: 2005-08-29 接受日期: 2005-09-06
Protective effect of pantoprazole on gastric mucosal lesions in rats and its mechanism
Qiao-Liang Le, Zhi-Jian Zhang, Ke-Rong Lin, Wen Wang
Qiao-Liang Le, Zhi-Jian Zhang, Ke-Rong Lin, Wen Wang, Department of Gastroenterology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, Fujian Province, China
Correspondence to: Qiao-Liang Le, Department of Gastroenterology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, Fujian Province, China. leql@sina.com
Received: 2005-08-29 Accepted: 2005-09-06
Abstract
AIM: To explore the protective effect of pantoprazole on the gastric mucosal lesions in rats and its related mechanism.
METHODS: Before the gastric mucosal lesion was in-duced by pure alcohol, the rats were intravenously injected with pantoprazole (20 mg/kg), Nω-nitro-L-arginine methyl ester (L-NAME, 4 mg/kg), and L-arginine (250 mg/kg). The gastric mucosal blood flow (GMBF) was detected by laser Doppler flowmetry (LDF), and the level of NO-2/NO-3 in the gastric mucosa and serum was measured by cadmium granulation reduction and colorimetric method. The ulcer index (UI), the severity of tissue necrosis, and neutrophils infiltration were observed.
RESULTS: Compared with that in the control group, the UI was significantly decreased (5.7±2.1 vs 25.4±2.5, P <0.01), and the degrees of tissue necrosis and neutrophils infiltration were markedly lightened. The protective effect of pantoprazole was significantly decreased by L-NAME. The inhibitory effect of L-NAME was antagonized by prior administration of L-arginine. The GMBF and the content of NO-2/NO-3 in gastric mucosa and serum were increased by the intravenous administration of pantoprazole ......
您现在查看是摘要介绍页，详见PDF附件(880KB，5页)。