大肠癌组织Ets-1,MMP-1和VEGF的表达及意义
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洪 玮, 刘南植, 张 庆, 李秀梅, 倪 志
转录因子Ets-1;基质金属蛋白酶-1;血管内皮生长因子;大肠癌,洪玮,刘南植,张庆,李秀梅,倪志,洪玮,通讯作者:,Expressiono
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洪玮, 刘南植, 张庆, 李秀梅, 倪志, 华中科技大学同济医学院附属同济医院消化内科 湖北省武汉市 430030
洪玮, 女, 1980-12-02生, 安徽六安人, 汉族, 华中科技大学同济医学院消化内科在读硕士研究生, 主要从事消化系肿瘤的研究.
通讯作者: 洪玮, 430030, 湖北省武汉市汉口解放大道1095号, 华中科技大学同济医学院附属同济医院消化内科. hongwei_80@126.com
电话：027-83663612 传真：027-83663585
收稿日期: 2005-09-28 接受日期: 2005-10-11
Expression of E26 transformation-specific-1, matrix metalloproteinases-1 and vascular endothelial growth factor in colorectal carcinoma
Wei Hong, Nan-Zhi Liu, Qing Zhang, Xiu-Mei Li, Zhi Ni
Wei Hong, Nan-Zhi Liu, Qing Zhang, Xiu-Mei Li, Zhi Ni, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Wei Hong, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. hongwei_80@126.com
Received: 2005-09-28 Accepted: 2005-10-11
Abstract
AIM: To study the expression of E26 transformation-specific-1 (Ets-1), matrix metalloproteinases-1 (MMP-1) and vascular endothelial growth factor (VEGF) in human colorectal carcinoma, and to explore the role of Ets-1 in the angiogenesis and metastasis of carcinoma.
METHODS: The expression of Ets-1, MMP-1 and VEGF were detected in colorectal carcinoma (n = 61) and normal colon tissues (n = 21) by the immunohistochemical method respectively.
RESULTS: Ets-1, MMP-1 and VEGF were negatively expressed in all normal mucosal tissues. The positive rates of Ets-1, MMP-1 and VEGF expression were 75.4%, 78.7% and 82.0% in colorectal carcinoma respectively. No significant correlation was found between their positive rates and tumor′s size as well as the differentiation (P >0.05). The expression of Ets-1, MMP-1 and VEGF were significantly correlated with Duke’s staging (χ2 = 10.718, P <0 ......
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