载脂蛋白B基因单核苷酸多态性与非酒精性脂肪性肝病
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姚 华, 李玉华
载脂蛋白B; 单核苷酸多态性; 非酒精性脂肪性肝病,姚华,李玉华,通讯作者:,Relationshipbetweensin
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姚华, 新疆医科大学附属中医医院党委书记 新疆维吾尔族自治区乌鲁木齐市 830000
李玉华, 新疆医科大学研究生处 新疆维吾尔族自治区乌鲁木齐市 830054
姚华, 男, 1959-01-06生, 山东省曹县人, 汉族, 2001年新疆医科大学劳动卫生与环境卫生学博士, 教授, 主要从事环境疾病与基因的研究.
新疆乌鲁木齐市科学技术项目, No.Y31102
通讯作者: 姚华, 830000, 新疆维吾尔族自治区乌鲁木齐市, 新疆医科大学附属中医医院. yaohua01@sina.com
电话: 0991-5840541
收稿日期: 2005-08-06 接受日期: 2005-08-25
Relationship between single nucleotide polymorphism of apolipoprotein B gene and nonalcoholic fatty liver disease
Hua Yao, Yu-Hua Li
Hua Yao, Affiliated Hospital of Tranditional Chinese Medicine, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Yu-Hua Li, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
Supported by the Science and Technology Foundation of Urumqi, No.Y31102
Correspondence to: Dr. Hua Yao, Affiliated Hospital of Tranditional Chinese Medicine, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. yaohua01@sina.com
Received: 2005-08-06 Accepted: 2005-08-25
Abstract
AIM: To investigate the relations of single nucleotide polymorphism (SNP) of the apolipoprotein B (ApoB) gene at MspⅠ, XbaⅠ and EcoRⅠ sites with the path-ogenesis of nonalcoholic fatty liver disease (NAFLD).
METHODS: The SNP of ApoB gene at MspⅠ, XbaⅠ and EcoRⅠsites was analyzed using polymerase chain reaction and oligonucleotide arrays in 299 patients with NAFLD and 278 healthy controls. Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), ApoB and ApoAⅠwere also detected in the blood samples from those patients and controls.
RESULTS: The frequencies of the rare allele M- at MspⅠsite and X+ at XbaⅠsites were significantly higher in NAFLD patients than those in the controls (M-: 0 ......
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