熊胆粉对二甲基亚硝胺诱发大鼠肝纤维化的抑制作用
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权明吉, 金仁顺, 朴 龙, 朴东明
熊胆粉;二甲基亚硝胺;肝纤维化;大鼠,权明吉,金仁顺,朴龙,朴东明,通讯作者:,Inhibitoryeffectsofbearbilepowderon
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权明吉, 金仁顺, 朴龙, 朴东明, 延边大学医院病理科 吉林省延吉市 133000
通讯作者: 朴东明, 133000, 吉林省延吉市局子街119号, 延边大学医院病理科. pdm11172000@yahoo.com.cn
电话: 0433-2660121 传真: 0433-2513610
收稿日期: 2005-08-29 接受日期: 2005-09-06
Inhibitory effects of bear bile powder on dimethylnitrosamine-induced liver fibrosis in rats
Ming-Ji Quan, Ren-Shun Jin, Long Piao, Dong-Ming Piao
Ming-Ji Quan, Ren-Shun Jin, Long Piao, Dong-Ming Piao, Department of Pathology, Hospital of Yanbian University, Yanji 133000, Jilin Province, China
Correspondence to: Dong-Ming Piao, Department of Pathology, Hospital of Yanbian University, 119 Juzi Street, Yanji 133000, Jilin Province, China. pdm11172000@yahoo.com.cn
Received: 2005-08-29 Accepted: 2005-09-06
Abstract
AIM: To investigate the inhibitory effect of bear bile powder on rat liver fibrosis induced by dimethylnitrosamine (DMN).
METHODS: A total of 30 rats were randomly divided into 3 groups: normal control group, model group, and bear bile group (10 in every group). The rat liver fibro-sis model was induced by peritoneal injection of DMN (10 g/L) for 4 wk. At the same time, the rats in the bear bile group received bear bile powder (400 mg/kg) orally once a day for 4 wk. Then the activities of serum alanine transaminase (ALT), aspartate transaminase (AST), and the contents of total protein (TP) were detected. Meanwhile, the pathological changes of liver tissues were observed under light microscope after HE staining, and the area density of collagenous fiber were examined. The amount and distribution of Kupffer cell (KC) and hepatic stellate cell (HSC) were detected by immunohistochemical SP method through the distribution of ED1 and α-smooth muscle actin (α-SMA).
RESULTS: Compared with that in the model group, the level of serum ALT was decreased, and AST was significantly decreased (4 370.87±1 338.60 nkat/L vs 5 741 ......
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