原发性胆汁性肝硬化与自身免疫性胆管炎的临床特征和HLA-DRBl等位基因分析
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陈 嵩, 朱刚剑, 邓国宏, 朱 妍
肝硬化; 胆汁性; 肝炎; 自身免疫性; 胆管炎; 重叠综合征,原发性胆汁性肝硬化与自身免疫性胆管炎的临床特征和HLA-DRBl等位基因分析
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陈嵩, 邓国宏, 朱妍, 第三军医大学西南医院全军感染病研究所 重庆市 400038
朱刚剑, 荆州市第二人民医院感染科 湖北省荆州市 434000
陈嵩, 男, 1963-09-22生, 贵阳市人, 汉族, 博士, 现为第三军医大学西南医院全军感染病研究所主任医师、副教授, 主要从事慢性肝炎的基础与临床研究.
通讯作者: 陈嵩, 400038, 重庆市, 第三军医大学西南医院全军感染病研究所. cs196@medmail.com.cn
电话: 023-68754475
收稿日期: 2005-08-29 接受日期: 2005-09-06
Clinical pathology and HLA-DRB1 allele associations of primary biliary cirrhosis and autoimmune cholangitis in Han Chinese
Song Chen, Gang-Jian Zhu, Guo-Hong Deng, Yan Zhu
Song Chen, Guo-Hong Deng, Yan Zhu, Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China
Gang-Jian Zhu, Institute of Infectious Diseases, the Second Hospital of Jingzhou City, Jingzhou 434000, Hubei Province, China
Correspondence to: Song Chen, Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China. cs196@medmail.com.cn
Received: 2005-08-29 Accepted: 2005-09-06
Abstract
AIM: To analyze the clinical and pathological characte-ristics of both primary biliary cirrhosis (PBC) and auto- immune cholangitis (AIC), and to explore their associ-ations with HLA-DRB1 alleles in Han Chinese.
METHODS: Of 94 patients diagnosed with PBC, 12 cases of AIC and 9 cases of overlap syndrome of PBC and au-toimmune hepatitis (AIH) were identified. The clinical manifestations and pathological changes exhibited in the liver biopsies from AIC, pure PBC and overlap syndrome were comparatively analyzed. The frequencies of HLA-DRB1 alleles were determined in AIC and PBC patients and healthy controls by polymerase chain reaction with sequence specific primers.
RESULTS: The age, sex, clinical manifestations, bio-chemical markers and histological findings were not significantly different between the AIC and pure PBC patients ......
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