鼻咽癌__(期刊论文)

鼻咽癌调强放射治疗和三维适形放射治疗计划比较分析

http://www.100md.com 《新疆医科大学学报》 2005年第8期

鼻咽癌,,鼻咽癌；调强放射治疗；三维适形放射治疗；治疗计划比较,1材料与方法,2结果,3讨论,参考文献:

     摘要: 目的：探讨调强放射治疗(IMRT)鼻咽癌的优势,以改进放射治疗技术。方法：对7例T2~3N1~3期鼻咽癌进行IMRT和三维适形放射治疗(3DCRT)计划的比较，每一例各设计一个IMRT和3DCRT治疗计划，给予95%计划靶体积(PTV) 50 Gy的处方剂量，用等剂量分布曲线和剂量体积直方图(DVH)评价治疗计划，评价参数包括平均剂量、适形指数(CI)、剂量不均匀性指数(HI)、D5%、V95%和各重要器官受量等。结果： IMRT和3DCRT各参数值：平均剂量分别为(54.0±1.5) Gy和(55.1±0.5) Gy, CI分别为0.85±0.01、0.61±0.03,HI分别为1.15±0.05、1.23±0.05，D5%分别为(57.3±0.2) Gy和(60.7±1.2) Gy,V95%分别为(98.8±0.53)%和(96.8±2.01)%，PTV靶区剂量除平均剂量和V95%外，其它各项参数差异均有统计学意义(P<0.05)。重要器官受量：脊髓最大剂量分别为(41.7±2.5) Gy和(46.4±2.7) Gy，差异有统计学意义(P<0.01)，其它参数均较接近，差异无统计学意义。结论：鼻咽癌IMRT计划优于CRT，是治疗鼻咽癌的理想选择。

    关键词：鼻咽癌；调强放射治疗；三维适形放射治疗；治疗计划比较

    Comparison of plans of intensitymodulated radiotherapy with 3Dconformal radiotherapy for nasopharyngeal carcinoma

    XU Suling, MA Donghui, WANG Ruozheng, et al

    (Centre of Radiotherapy, Affiliated Tumor Hospital, Xinjiang Medical University,Urumqi 830011, China)

    Abstract: Objective: To investigate superiority of intensitymodulated radiotherapy (IMRT) for nasopharyngeal carcinoma, in order to improve technology of radiotherapy for nasopharyngeal carcinoma. Methods: IMRT and CRT plans were compared for seven patients with nasopharyngeal carcinoma with staging of T2~3N1~3. For each patient, one IMRT and one CRT plans were designed with a prescribed dose of 50 Gy to at least 95% of plan target volume (PTV). The following parameters of these plans in each patient were compared: isodose distributions line, dosevolume histogram (DVH), D5%, V95% and the dose of protective organs, etc. Results: For IMRT and one CRT, ......

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