四种肿瘤标志物在原发性肝癌诊断中的应用价值
肿瘤,,原发性肝癌;,甲胎蛋白;,L岩藻糖苷酶;,谷氨酰转肽酶;,5′核苷酸;,肿瘤标志物,1资料与方法,2结果,3讨论,参考文献:
摘要: 目的: 探讨肿瘤标志物甲胎蛋白(AFP)、L岩藻糖苷酶(AFU)、谷氨酰转肽酶(GGT)、5′核苷酸(5′NT)在原发性肝癌(PHC)诊断中的应用价值。 方法: 110例分为2组,PHC组70例,正常对照组40例,采用电化学发光仪检测2组血清AFP水平,采用LX20型生化仪检测2组AFU、GGT、5′NT 水平,并分析4种肿瘤标志物对PHC的诊断价值。结果: PHC组血清AFP、AFU、GGT、5′NT水平均明显高于正常对照组,差异有统计学意义(P<0.05~0.01)。AFP、GGT、5′NT、AFU对PHC诊断的敏感性分别为71.42%、68.57%、32.86%、21.43%,AFU、GGT、5′NT检测的特异性均为100.00%,AFP检测特异性为95.00%,4种血清肿瘤标志物联合检测敏感性为92.85%。结论: 肿瘤标志物AFP、AFU、GGT、5′NT 对PHC有一定的诊断价值,4种肿瘤标志物联合检测可提高诊断PHC的敏感性。关键词: 原发性肝癌; 甲胎蛋白; L岩藻糖苷酶; 谷氨酰转肽酶; 5′核苷酸; 肿瘤标志物
Diagnostic application value of four kinds of tumor markers in primary hepatocellular carcinomaMU Chaodong, XU Yi, DU Ping, et al
(Department of Clinical Laboratory, Affiliated Cancer Hospital,Xinjiang Medical University, Urumqi 830000, China )
Abstract: Objective: To probe the diagnostic value of a1fetoprotein(AFP), aLfucosidase(AFU), rglutamyl transpeptidase(GGT), 5′nucleotidase(5′NT) for primary hepatocellular larcinoma (PHC). Methods: One hundred and ten case were divided into PHC group and normal control group. Electrochem cuminescence method was used to detect serum AFP, LX20 biochemical instrument for AFU, GGT and 5′NT of these two groups. Results: The serum level of AFP, AFU, GGT and 5′NT in PHC group were significantly higher than that of in control group (P<0.05~0.01). The sensibility of AFP, GGT, 5′NT and AFU for PHC were 71.42%, 68.57%, 32.86% and 21.43%. The specificity of AFU, GGT, 5′NT, AFU were 100.00%, 100.00%, 100.00%, 95.00%, respectively. The sensibility of these four tumor markers was 92.85%. Conclusions: These four tumor marker have some diagnostic value for PHC. ......
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