肾上腺素受体_

β2肾上腺素能受体基因+46位多态性与新疆哈萨克族人超重肥胖的关系

http://www.100md.com 《新疆医科大学学报》 2005年第1期

肾上腺素受体,,β2肾上腺素受体(β2AR)；基因多态性；体重指数；肥胖；哈萨克族,1资料与方法,2结果,讨论,参考文献：

     摘要: 目的：通过观察β2肾上腺素能受体基因(β2adrenergic receptor, β2AR、ADRB2)+46A→G (Arg16/Gly)多态性与体重指数(BMI)的关系，研究其与哈萨克族人超重肥胖的关系。方法：采集120例35～65岁哈萨克族人的遗传标本，按WHO超重和肥胖划分标准以BMI<25 kg/m2、25～29.9 kg/m2、≥30 kg/m2 将人群划分为正常、超重及肥胖3组，采用allelespecific PCR方法检测和分析该人群β2AR基因+46A→G多态性,观察各基因型和等位基因频率在不同BMI水平的分布及其与超重肥胖的关系。结果：该人群β2AR+46位基因型频率为AA 0.39，AG 0.37，GG 0.24；A等位基因频率为0.58，G等位基因频率为0.42；3组间相应AA、AG、GG及A、G基因型和等位基因频率分别为0.37、0.39、0.24、0.56 、0.44；0.47、0.33、0.20、0.63、0.37和0.29、0.38、0.33、0.48、0.52，3组基因型及等位基因频率差异均无统计学意义(P>0.05)。结论：哈萨克族人群β2AR基因存在+46 A→G (Arg16/Gly)多态性，但该位点多态性与哈萨克族人群超重肥胖无关。

    关键词: β2肾上腺素受体(β2AR)；基因多态性；体重指数；肥胖；哈萨克族

    The Association Study between β2Adrenergic Receptor +46 Variant and Body Mass Index (BMI) in Kazak of Xinjiang

    LUO Qin, LI Nanfang, ZHOU Ling, et al

    (Hypertension Unit, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China)

    Abstract: Objective: To investigate the association of β2Adrenergic Receptor +46 Variant with overweight and obesity by BMI in kazak of Xinjiang. Methods: The study recuited 120 kazak aged from 35 to 65, who were devided into three groups according to WHO measures of overweight and obesity (BMI <25 kg/m2, 25～29.9 kg/m2, ≥30 kg/m2). Allelespecific ploymerase chain reaction (PCR) procedures were developed to genetype the Arg16/Gly variant of β2AR gene. Results: The frequencies of genotypes AA, AG, GG and alleles A,G of β2AR +46 variant in total population were 0.37, 0.39, 0.24 and 0.56, 0.44; in group of BMI <25 kg/m2 were 0.39, 0.37, 0.24 and 0.56, 0.44; in group of BMI 25~29.9 kg/m2 were 0.47、0.33、0.20 and 0.58, 0.42; and in group of BMI ≥30 kg/m2 were 0.39, 0.38, 0.33 and 0.48, 0.52, respectively. There were no significant difference in frequencies of both genotypes and alleles between the three groups of BMI in this population (P>0.05). Conclusions: These data show that +46A→G (Arg16/Gly) variant of β2AR gene was found in kazak, but may not correlate to BMI, overweight and obesity in this population. ......

百拇医药网 http://www.100md.com/html/DirDu/2005/11/05/79/31/00.htm

您现在查看是摘要页，全文长 12906 字符。