溃疡性结肠炎_____溃结安；_溃疡性结肠炎；

溃结安对兔及溃疡性结肠炎模型大鼠血小板聚集的影响

http://www.100md.com 《新疆医科大学学报》 2005年第1期

溃疡性结肠炎,,溃结安；,溃疡性结肠炎；,血小板聚集,1材料与方法,2结果,3讨论,参考文献:

     摘要: 目的：研究溃结安对兔及溃疡性结肠炎(UC)模型大鼠血小板聚集的影响。方法： (1)麻醉兔后，颈动脉取血，制备富含血小板血浆(PRP),加入溃结安(0.45\,0.90\,1.80 g/L)，用多功能血小板聚集仪测定二磷酸腺苷(ADP)诱导的血小板聚集率。(2)利用 2,4,6三硝基苯磺酸(TNBS)诱发大鼠UC，溃结安(50\,100、200 mg/kg)灌肠20 d，摘眼球取血，制备 PRP，测定 ADP诱导的血小板聚集。结果：与空白对照组比较，溃结安(0.45、0.90、1.80 g/L)能明显抑制ADP诱导兔的体外血小板聚集率(P均<0.01)；与空白对照组比较，溃结安(50、100、200 mg/kg)灌肠能降低UC模型大鼠ADP诱导的血小板聚集率(P均<0.01);溃结安用药呈一定量效关系。结论：初步证实溃结安能在体内及体外降低ADP诱导动物的血小板聚集率。

    关键词：溃结安；溃疡性结肠炎；血小板聚集

    Effects of kuijiean on platelet agglomeration in rabbits and ulcerative colitis rats

    WU Hongli, MAO Xinming, ZHANG Fangyan, et al

    (Department of Pharmacology, College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective: To study the effects of kuijiean on platelet agglomeration induced by Adenosine diphosphate (ADP) in rabbits and TNBSinduced ulcerative colitis rats. Methods: Platelet agglomeration induced by ADP was determined with turbidity assay. Results: Kuijiean (0.45、0.90、1.80 g/L) might inhibit platelet agglomeration induced by ADP in rabbits (P<0.05). And kuijiean at a dosage of 50、100、200 mg/kg remarkably decreased the ADPinduced platelet agglomeration in TNBSinduced ulcerative colitis rats. These effects were related with dosage of giving drug. Conclusion: It demonstrated tentatively that kuijiean had an inhibitory effect on platelet agglomeration. ......

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