甲胎蛋白__

AFP、AFPL3和AFU联合检测在原发性肝癌诊断中的应用

http://www.100md.com 《新疆医科大学学报》 2005年第2期

甲胎蛋白,,原发性肝癌；甲胎蛋白；甲胎蛋白异质体；αL岩藻糖苷酶；诊断,1资料与方法,2结果,3讨论,参考文献：

     摘要：目的：探讨3种血清肿瘤标志物甲胎蛋白(AFP)、AFP异质体(AFPL3)和αL岩藻糖苷酶(AFU)联合检测对原发性肝癌(PHC)的互补诊断价值及对肝癌早期诊断的意义。方法：对我院2003年7月~2004年3月收治的49例PHC、50例慢性乙型肝炎和20例正常对照联合检测AFP、AFPL3和AFU水平，采用电化学发光法测定AFP和AFPL3水平，采用速率法测定AFU水平。结果：PHC组与慢性乙型肝炎组、正常对照组血清AFP水平相比差异有统计学意义(P<0.01)；PHC组与慢性乙型肝炎组和正常对照组的AFP均数相比差异有统计学意义；3项标志物单项检测的敏感性分别为65.3%、85.7%、49.0%；联合检测AFP和AFPL3或AFU可使检出率提高至92.1%和83.2%；3项指标联合检测PHC的检出率高达97.0%。结论：联合检测AFP、APFL3和AFU 3项指标可提高HPC尤其是AFP阴性HPC的诊断效率，对HPC的早期诊断有一定的指导意义。

    关键词: 原发性肝癌；甲胎蛋白；甲胎蛋白异质体；αL岩藻糖苷酶；诊断

    A study on the combined detection of AFP, AFPL3 and AFU in the diagnosis of primary hepatic cancer

    ZHANG Guoqing， WANG Bin， LIU Zhenjiang， et al

    (Department of Surgery, Affiliated Tumor Hospital ,Xinjiang Medical University,Urumqi 830011, China)

    Abstract： Objective: To study the complementary value of alpha fetoprotein (AFP), alphafetoprotein variant and αLfucosidase to the diagnosis of primary hepatic cancer. Methods: Serum AFP, alpha fetoprotein variant and αLfucosidase were measured in 49 cases with primary hepatic cancer and 50 cases with chronic hepatitis B and 20 normal cases. The three indices were compared and analyzed for the their complementary diagnostic values to primary hepatic cancer. Results: The diagnostic sensitivities of AFP, alphafetoprotein variant and αLfucosidase to primary hepatic cancer were 65.3%、85.7%、49.0% respectively. Simultaneous determination of AFP and alphafetoprotein variant or αLfucosidase could increase the sensitivities to 92.1% and 83.2% respectively. Furthermore, combines detection of these three indices could make the diagnostic sensitivity as high as 97.0%. Conclusion: The combined assay of serum tumor markers is valuable in the diagnosis of primary hepatic cancer, especially in AFP negative patients. ......

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