摘要：目的：评价短期激素替代疗法(HRT)治疗绝经后妇女更年期综合征的疗效及安全性。方法：选择绝经后有更年期综合征症状的妇女40例，给予结合雌激素片剂0.625 mg+安宫黄体酮4 mg(周期方案)，连续用药4个周期，同期选择相同条件的40例妇女作为对照组。观察改良Kupperman评分、血清促卵泡素(Fsh)、雌二醇(E2)、子宫内膜厚度等指标。结果：用药第1、3、4个月及停药1个月与治疗前及对照组相比，Kupperman评分均有明显下降，差异均有统计学意义(P<0.01)；停药第2、3个月与治疗前及对照组相比，Kupperman评分差异无统计学意义(P>0.05)。血清Fsh、E2水平在用药后有明显改善，与用药前相比，差异有统计学意义(P<0.01)；但在停药1周后又恢复到治疗前水平;经B超检查，治疗后的妇女子宫内膜厚度较治疗前有所增加，差异有统计学意义(P<0.01)，但内膜宫腔镜检查及内膜活检均在正常范围。结论：短期HRT治疗绝经后妇女更年期综合征的疗效明显，安全可靠。

    关键词：激素替代疗法；更年期综合征；绝经后

    Analysis of the efficacy and safety of short time HRT on the symptoms of postmenopausal

    LIN lin, DING Yan, HE Jin, et al

    (Department of Gynecology，First Affiliated Hospital, Xinjang Medical Univercity,Urumqi 830054, China)

    Abstract：Objective： To assess the efficacy and safety of short course HRT on the symptoms of postmenopausal. Metheods： 40 health women with postmenopausal syndrome received HRT 4 months. Compared with 40 health women with postmenopausal syndrome in the same time. To observe Kupperman index；Fsh、E2；The thickness of endometrium on B ultrasonogrphy etc. Results： Kupperman index in the 1th、3th 、4th month and after 1th month(P<0.01) , Fsh(P<0.01) decreased and E2 (P<0.01)increased markly after HRT； The thickness of endometrium increased(P<0.01) ......