摘要:目的 探讨Survivin蛋白表达与喉癌临床病理因素的相关性。 方法 采用免疫组织化学技术(SP法)对45例喉癌组织和7例正常喉黏膜组织标本进行Survivin蛋白表达情况检测。 结果 喉癌组织中Survivin蛋白阳性表达率为62.2%(28/45)，7例正常喉黏膜组织无Survivin蛋白表达。临床分期Ⅲ～Ⅳ期喉癌组织的Survivin蛋白阳性表达率高于Ⅰ～Ⅱ期喉癌组织(P<0.01);中、低分化喉癌组织的Survivin蛋白阳性表达率高于高分化喉癌组织(P<0.01);发生颈淋巴结转移的喉癌组织的Survivin蛋白阳性表达率高于无颈淋巴结转移的喉癌组织(P<0.01)。 结论 Survivin蛋白的表达与喉癌临床分期、病理分级和颈淋巴结转移有密切关系，它的高表达可能在喉癌的发生、发展和转移中起重要作用。

    关键词:Survivin蛋白;喉肿瘤;免疫组织化学

    Clinical significance of the expression of surviving in squamous cell of carcinoma of larynx.FULi-ping，LUYi-sheng，GUO Jian，et al.(Department of Pathology of Dongguan Municipal People's Hospital，Dongguan523018，Guangdong，P.R.Chi-na)

    Abstract:Objective To explore the expression of Survivin in squamous cell carcinoma of larynx and its relationship with histopathological factors. Methods The expressions of Survivin in laryngeal cancer of45cases and normal laryngeal tissues of7cases were studied by immunohistochemical S-P staining. Results It was found that the positive rate of Survivin in45cases of laryngeal squamous cell carcinoma was62.2%(28/45).In contrast ......