【摘要】 目的 探讨马来酸曲美布汀对肠易激综合征的治疗效果。方法 将诊断为肠易激综合征(IBS)的97例患者随机分成试验组(47例)和对照组(50例)，试验组给予马来酸曲美布汀，对照组使用复合维生素B作为安慰剂，两组疗程均为6周，治疗期间均停用其他药物，分别于治疗前及治疗的第2、4、6周及随访8、12周末进行症状评价及评分。结果 试验组治疗后积分明显下降，治疗前后比较差异有非常显著性(P<0.01)；对照组积分下降不明显，治疗前后比较差异无显著性(P>0.05)；治疗4周后两组间比较，试验组积分下降较对照组明显，差异有非常显著性(P<0.01)；治疗后两组疗效比较，试验组在2周后有效率达34%，8周和12周时分别达到83%和82%，疗效明显高于对照组，差异有非常显著性(P<0.01)。结论 马来酸曲美布汀对难治性功能性消化不良具有良好的治疗作用和安全性。

    【关键词】 马来酸曲美布汀；治疗；肠易激综合征

    Comparison study on trimebutine maleate in treatment of irritable bowel syndrome

    SONG Hui-qin,KOU Ji-guang,ZHANG Lei,et al.

    Xiaogan Central Hospital,Xiaogan 432100,China

    【Abstract】 Objective To study the effects of trimebutine maleate in the treating irritable bowel syndrome.Methods 97 patients with irritable bowel syndrome were randomly divided into testing group(47 IBS,trimebutine maleate 0.3g/d for 6 weeks)and conventional group(50 IBS,VitBco 6 tab/d for 6 weeks).Symptom score was recorded before and after taking drug.Results After taking drug,the symptom score significant decreasing from testing group(P<0.01);the symptom score non-significant decreasing from testing group(P>0.05).The efficacy of testing group after taking drug for 2,8,12 week was 34%,83%,82%respectively,significantly higher than the conventional group(P<0.01).Conclusion Trimebutine maleate has remarkable effectiveness and security in the treating irritable bowel syndrome. ......