孕酮_____雌二醇；孕酮；动作电位

雌、孕激素联合应用对豚鼠心室乳头肌动作电位的影响

http://www.100md.com 《新疆医科大学学报》 2005年第4期

孕酮,,雌二醇；孕酮；动作电位,1材料与方法,2结果,3讨论,参考文献:

     摘要: 目的：观察不同浓度17β雌二醇(17βestradiol,E2)与孕酮(progesterone,P)联合运用对豚鼠心室乳头肌细胞动作电位的影响。方法：采用常规玻璃微电极技术记录豚鼠心室乳头肌细胞动作电位。结果：(1)E2与P单独应用可使动作电位时程(APD90、APD)延长，APD20缩短，APA、Vmax降低。(2)不同浓度E2与P联合应用，P可加强E2的效应，这种作用可能呈现浓度依赖性。结论：E2与P可能抑制钾、钠通道，应用时应以低浓度为宜。

    关键词: 雌二醇；孕酮；动作电位

    Electrophysiological effects of estradiol with progesterone on action potential of guinea pig papillary muscle

    JIANG Ping, Parhat, SHAO Cihui, et al

    (Department of Physiology, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective：To study the effects of estradiol with progesterone on action potential(AP) of guinea pig papillary muscle. Methods: Using conventional glass microelectrode record action potential. Results: E2 or P slowed down the maximal rate of rise of phase 0 (Vmax) of AP, decreased the action potential amplitude(APA), prolonged AP duration(APD90 and APD) and ERP. Conclusion: All the results suggested that E2 or P inhibits the K+ channels may be also the Na+ channels of guinea pig papillary muscle. P can strenghten E2 in some degree. ......

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