摘要：目的 临床观察抑肽酶在小儿体外循环手术中对肺损伤的保护作用。方法 将78例0.5~2岁先天性心脏病患儿分为抑肽酶用药组(38例)和对照组(40例)，对比观察术后肺部并发症发生率、呼吸机应用时间、术后肺泡-动脉血氧压差。结果 实验组与对照组比较，肺部并发症发生率低、呼吸机应用时间短、术后肺泡-动脉-血氧分压差低(p<0.01)。结论 体循环中应用抑肽酶可以减轻肺损伤、保护肺功能。

    关键词：抑肽酶，体外循环，肺保护

    Clinical Observation on The Protective Effect of Aprotinin on Lungs in Infants Undergoing Cardiopulmonary Bypass

    LI Yong-wu, LIU Hai-xia, WANG Ping-fan, YANG Neng-shan

    (Department of cardiovascular surgery, Henan provincial chest hospital, Zhengzhou 450003, China )

    Abstract: OBJECTIVE To observe the clinical effect of aprotinin on lung protection in infants undergoing cardiopulmonary bypass. METHODS 78 infants with ventricular septal defects aged 0.5~2 years, weight 5~12kg, were randomly divided into two groups. Aprotinin group and control group. Patients in the aprotinin group received dose of aprotinin (50000KIU/kg). The control group received the same volume of saline. Chest X-rays pictures of chest were taken 1 hour, 12 hour, 24 hours after operation for existence of pulmonary complications. Alveolar-arterial oxygen gradient were recorded 1 hour, 4 hours and 24 hours after operation. Time of intubation during ICU were also recorded.RESULTS Compared with the control group, patients in the Aprotinin group showed lower rate of occurrence of pulmonary complications, shorter time of intubation and lower A-aDO2 after operation (P<0.01).CONCLUSION This observation suggests that aprotinin may have a protective effect on lungs in infants undergoing CPB. ......