草棉花总黄酮_____草棉花总黄酮；

草棉花总黄酮对大、小鼠急性实验性肝损伤的影响

http://www.100md.com 《新疆医科大学学报》 2005年第3期

草棉花总黄酮,,草棉花总黄酮；,急性实验性肝炎；,谷丙转氨酶；,超氧化物歧化酶；,丙二醛,2结果,3讨论,参考文献:

     摘要：目的：初步探讨草棉花花瓣提取物总黄酮(FGF)对大、小鼠急性实验性肝损伤的影响。方法：用DGalN(400 mg/kg)及CCl4(50%橄榄油溶液,5 ml/kg)对大鼠进行攻击；用大剂量PAR(200 mg/kg)对小鼠进行攻击，分别建立3种急性实验性肝损伤模型，观察FGF对大、小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、肝组织超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量以及肝组织病理变化等指标的影响。结果：发现FGF对DGalN引起的肝损伤模型(400 mg/kg×7 d)的ALT虽比模型组低，但差异无统计学意义(P>0.05)；FGF (800 mg/kg×7 d)使ALT明显降低，与模型组相比，差异有统计学意义(P<0.01)；FGF(400、800 mg/kg)使AST均明显降低，差异有统计学意义(P<0.01)；FGF两个剂量组均使MDA的含量降低。FGF两个剂量组(400、800 mg/kg)对CCl4引起的肝损伤模型均使血清ALT、AST水平明显降低，并能提高肝组织SOD活性，降低MDA含量。FGF(800、1 200 mg/kg)对PAR引起的肝损伤模型均使血清ALT、AST水平明显降低，并能提高肝组织SOD活性，降低MDA含量。在3种模型中FGF均能明显改善肝组织病理损伤程度。结论：FGF对大、小鼠3种化学性肝损伤有明显的保护作用，其机制可能与FGF的抗氧化作用有关。

    关键词：草棉花总黄酮；急性实验性肝炎；谷丙转氨酶；超氧化物歧化酶；丙二醛

    Hepatoprotective effect of the total Flos Gossypium Flavonoid on the acute experimental hepatitis

    Subat, Parhat, Asiya

    (College of Pharmacay， Xinjiang Medical University， Urumqi 830054,China)

    Abstract: Objective: The effects of Flos Gossypium Flavonoid (FGF) on the acute experimental hepatitis induced by DGalactasamine (DGalN), carbon tetrachloride (CCl4) and paracetamol (PAR) were observed. Methods: Experimental hepatitis animal models were established in Wistar rats by an single intraperitoneal injection of DGalN (400 mg/kg), a subdermal injection of CCl4 (5 ml/kg, 1∶1 in olive oil) and an intraperitoneal injection of Par (200 mg/kg) in mice, respectively. Serum Alanine transferase (ALT), Aspartate tranferase (AST), liver super oxide dismutase (SOD), malondialdehyde (MDA) were examined. Results: FGF at a dose of 400 mg/kg decreased the serum ALT level but there is no significant difference compared with the hepatitis model induced by DGalN (P>0.05); there was an significant difference when it was administered at a dose of 800 mg/kg (P<0.01), both dosages lowered the liver MDA content in the CCl4 induced hepatitis model, both dosages (FGF400 mg/kg), FGF significantly decreased serum ALT and AST elevation at both dosages and increased the SOD and GSH activities while lowered MDA content. In the PAR induced hepatitis model serum ALT and AST levels reduced with a preadministration of FGF at dosages of 800 mg/kg and 1200 mg/kg, and elevation in the SOD activity and a drop in MDA content were observed. Conclusion: FGF possesses a significant hepatoprotection against the three kinds of chemically induced hepatitis. ......

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