【摘要】 目的 观察不同剂量雌激素对去势大鼠血脂代谢的影响。方法 选用日龄120天雌性SD大鼠，随机分为2组：去卵巢组(OVX组)和假去卵巢组(Sham组)，OVX组于术后60天再随机分为4组皮下注射不同剂量雌激素。于第10次注射雌激素后第2天全部动物均取血，离心分离血清，用酶法测定血脂，并进行相关分析。结果 OVX组与Sham组比较，血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)都明显升高(P<0.05或P<0.01)，高密度脂蛋白胆固醇(HDL-C)显著降低(P<0.01)。雌激素使OVX大鼠TC、LDL-C显著降低，HDL-C显著升高，且有一定的量效关系。但雌激素对TG的作用，低剂量组较对照组显著升高(P<0.05);中剂量组与对照组比较无明显变化(P>0.05)，而较高剂量组显著降低(P<0.01)；高剂量组较对照组、低剂量组和中剂量组都显著降低(均P<0.01)。结论 雌激素对OVX大鼠升高的TC和LDL-C及降低的HDL-C有治疗作用，且有一定量效关系；但对TG的治疗作用是复杂的，不同剂量、不同治疗方法和不同种属的作用不同。

    【关键词】 雌激素；血脂；去势大鼠

    Effects of different dose estrogen on the metabolism of serum lipids in ovariectomized rats

    NI Chu-min,HUANG Yi-heng,LIU HAO-yu,et al.

    Guangdong Medical College,Zhanjiang 524023,China

    【Abstract】 Objective To observe the effects of different dose estrogen on the metabolism of serum lipids in ovariectomized(OVX) rats.Methods 120 days old adult Sprague-Dawley(SD) female rats were randomly divided into 2 groups:OVX group and Sham group.The OVX rats were injected with different dose estrogen every three day from the 60th day after operation.The second day after the 10th injected,all rats were sacrificed,and the levels of serum lipids were measured.Results Comparing with Sham group,the serum levels of total cholestrol(TC),triglyceride(TG),low density lipoprotein-cholestrol(LDL-C) of OVX group were obviously higher(P<0.05 ......