【摘要】 目的 研究血清胆红素水平与冠状动脉病变程度的关系，为冠心病(CHD)的预防、治疗探索新思路。方法 将116例患者按冠状动脉造影结果分为冠心病组(CHD组)和非冠心病组(非CHD组)，检测血清胆红素及冠心病一些重要传统危险因素，比较两组血清胆红素水平差异，对血清胆红素水平与冠状动脉病变程度之间的关系进行双因素及多因素分析，对血清胆红素水平与冠心病传统危险因素进行多因素分析。结果 (1)CHD组血清总胆红素(TBIL)、直接胆红素(DBIL)水平低于非CHD组(P<0.01)。(2)双变量分析显示冠状动脉病变积分(LNCCS)与TBIL和DBIL均呈负相关，相关系数分别为r=0.450(P<0.01)和r=-0.774(P<0.01)。(3)多元逐步回归分析显示血清DBIL进入回归方程，LNCCS和DBIL呈负相关。DBIL与LDL、性别、年龄相关，间接胆红素(IBIL)与HDL和LDL相关。结论 血清胆红素水平与冠状动脉病变程度呈独立负相关，低血清胆红素水平是冠状动脉粥样硬化的独立危险因素。

    【关键词】 血清胆红素；冠心病；危险因素；冠状动脉病变程度；血脂

    Association of serum bilirubin concentration with severity of coronary artery disease

    WU Peng-tao,YU Hong,WU Geng,et al.

    Department of Cardiology,Baoding Second Hospital,Baoding 071051,China

    【Abstract】 Objective To study the association of serum bilirubin concentration with severity of coronary artery disease,and to explore new idea for prevention and therapy of coronary heart disease.Methods 116 patients who underwent coronary angiography(CAG)to determine their severity degree of coronary artery disease.According to the results of CAG,all the cases were classified as CHD group and non-CHD group,all the samples were tested for serum bilirubin and some important traditional risk factors of CHD,observe the differences of serum bilirubin between the two groups.The association of bilirubin and CCS was analyzed by two-sample test for independent samples,linear correlation and multiple linear stepwise regression.The association of bilirubin and other risk factors of CHD was analyzed by multiple linear stepwise regression.Results (1)The level of TBIL and DBIL in non-CHD group are higher than those in CHD group(P<0.01).(2)Linear correlation reveal that both TBIL and DBIL have negative correlation with LNCCS,r=-0.450(P<0.01)and r=-0.774(P<0.01)respectively.(3)Multiple linear stepwise regression analysis showed DBIL enter regression equation,LNCCS has negative correlation with DBIL.DBIL is relative to LDL,GENDER and AGE. IBIL is relative to HDL and LDL.Conclusion Serum bilirubin has an inverse association with severity of coronary artery disease,low serum bilirubin concentration is an independent risk factor of CHD. ......