弥散性血管内凝血快速实验室诊断指标的价值
血液凝固,,血液凝固；弥散性血管内凝血；快速实验诊断,1对象与方法,2结果,3讨论
【摘要】 目的 对弥散性血管内凝血(DIC)实验室快速诊断指标的敏感性、特异性及其改变的意义进行比较评估，提供理想的检测方案。方法 采用了一般实验室可行的DIC实验室诊断指标如抗凝血酶活性(AT∶A，发色底物法)检测、凝血酶原时间(PT)、纤维蛋白原定量(Fbg)、D二聚体(D-D)、鱼精蛋白副凝固试验(3P)、凝血酶凝固时间(TT)等试验。结果 健康正常人77例，临床病例166例，在DIC组AT∶A 敏感率是91.9%， PT是89.2%，Fbg是86.5%，D-D是82.4%，3P是79.7%，TT是66.2%。结论 目前国内采用的DIC实验室诊断指标快捷实用，并具有一定的特异性和敏感性，但就诊断DIC而言多数存在较高的假阳性与假阴性。【关键词】 血液凝固；弥散性血管内凝血；快速实验诊断
The value of rapid laboratory diagnostic indicators for disseminated intravasc
ular coagulation
GONG Bo，YIN Ding-jia，DU Jing-yun，et al.
Department of Clinical Laboratory, Shanghai Furu Hospital, Shanghai 200051，China
【Abstract】 Objective To study the sensitivity and specificity of the rapid laboratory diagnostic indicators for DIC. Methods 77 samples of healthy controls and 166 samples of DIC were detected by antithrombin (AT: T),prothrombin time (PT), fibrinogen (Fbg), D-dimer (DD), protamine paracoagulation test (3P) and thrombin time (TT). Results In the DIC group, the sensitivity of AT: A was 91.9%, that of PT was 892%, Fbg was 86.5%, DD was 82.4%,3P was 79.7% and TT was 79.7%. Conclusion The laboratory indicators can give a swift, practical, sensitive and specific method to diagnose DIC. But they cannot avoid high false positive and false negative. ......
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