【摘要】 目的 探讨增龄和高血压病对动脉弹性功能的影响。方法 采用改良Windkessel模型为基础的脉搏波分析法，检测204例健康志愿者(15～80岁)和46例原发性高血压病人(35～70岁)的大动脉弹性指数(C1)和小动脉弹性指数(C2)，评价增龄和高血压病对动脉弹性功能的影响。结果 健康志愿者C1和C2随着年龄增长而降低，与年龄呈负相关(r=-0.628，P<0.001；r=-0.595，P<0.001)。原发性高血压病人的C1和C2分别为(9

    .31±3.85)×10ml/mmHg和(3.57±1.62)×100ml/mmHg，明显低于年龄匹配的健康志愿者(15.13±4.14)×10ml/mmHg和(7.89±2.91)× 100ml/mmHg。高血压病人C1和C2与收缩压(r=-0.37，P<0.05；r=-0.39，P<0.05)和脉压(r=-0.39，P<0.05；r=-0.43，P<0.05)呈负相关。结论 增龄和高血压病导致动脉弹性功能损伤，动脉弹性功能检测为临床评价血管结构和功能损害及其危险分层提供了一种替代方法。

    【关键词】 动脉弹性；内皮；增龄；原发性高血压；血管

    Effect of human aging and hypertension on arterial elasticity

    WANG Yan,TAO Jun,YANG Zhen,et al.

    Department of Cardiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China

    【Abstract】 Objective The present study was performed to evaluate effects of aging and hypertension on arterial elasticity.Methods Using modified Windkessel model of the circulation and pulse waveform analysis,large artery elasticity indices (C1) and small artery elasticity indices (C2) of 204 healthy subjects (age 15～80 years) and 46 essential hypertensive patients (age 35～70 years) were measured.Age- and hypertension-related arterial elasticity changes were examined.Results C1 large artery and C2 small artery elasticity indices of healthy subjects were reduced with advancing age.C1 large artery and C2 small artery elasticity indices were negatively correlated with age (r=-0.628,P<0.001;r=-0.595,P<0.001).C1 large artery and C2 small artery elasticity indices in patients with essential hypertension compared with the age-matched healthy subjects were (9.31±3.85)ml/mmHg×10 versus (15.13±4.14)ml/mmHg×10(P<0.001) and (3.57±1.62)ml/mmHg×100 versus (7.89±2.91)ml/mmHg×100 (P<0.001),respectively,and significantly lower than the corresponding healthy subjects.There was a negative association between C1 large artery and C2 small artery elasticity indices and systolic blood pressure (r=-0.37,P<0.05;r=-0.39,P<0.05) and pulse pressure (r=-0.39,P<0.05;r=-0.43,P<0.05) in patients with essential hypertension. ......