【摘要】 目的 分析贵州省近年来人群中脊灰病毒变化趋势，探索疫苗衍生株脊髓灰质炎病毒循环(cVDPVs)发生的原因。

    方法 对贵州省2000～2004年急性弛缓性麻痹(AFP)病例及接触者粪便标本的脊灰病毒学检测结果进行对比分析。

    结果 (1)脊灰病毒的阳性检出率波动在7.1%～15.9%之间，平均11.2%。(2)2000～2004年脊灰病毒的分离率和型别构成变化较大，Ⅰ型分离率和构成比逐年增高，至2003～2004年显著上升达高峰；Ⅱ型所占比例逐年降低，至2004年达最低；Ⅲ型稳步增高。(3)160株脊灰阳性毒株中，疫苗相关株146株(91.3%)，疫苗变异株7株(占4.4%)，疫苗衍生株(VDPVs)7株(4.4%)，7株VDPVs均为2004年分离到，其中Ⅰ型VDPVs 6株，Ⅱ型VDPVs 1株。

    结论 对脊灰病毒在人群中的变化趋势进行分析，可以预测VDPVs的发生和流行，可为提前采取控制措施提供依据。

    【关键词】 脊髓灰质炎病毒；疫苗衍生株脊髓灰质炎病毒；比较

    The comparison and analysis on the poliovirus isolation rate of Guizhou Province in 2000～2004

    YE Xu-fang,REN Gang,SU Fei,et al.

    Center for Disease Control and Prevention of Guizhou Province,Guiyang 550004,China

    【Abstract】 Objective To analyze the poliovirus variety trend in the crowd of Guizhou Province in recent years.Investigate the occurrence reason of the circulation of vaccine-derived poliovirus(cVDPVs).Methods Making a contrast and analysis to the result of the polio-virology surveillance which came from AFP case and contact stool specimens in 2000-2004 of Guizhou Province.Results (1)The poliovirus isolation rate of 2000～2004 was motioning among 7.1%～15.9% and average 11.2%.(2)The separation rate and the type constitute of PV have greatly varied.The type Ⅰ separation rate and constitute ratio have increased year by year,by the 2003-2004 years rising remarkablely to reacn the high peak;The type Ⅱ constitute ratio have decreased year by year and going to 2004 to reach lowest;the type Ⅲ is steady to increase.(3)160 strains PV were identified by the National Poliomyelitis Laboratory.Among them,146 strains were vaccine-associated PV(91.3%) ......