【摘要】 人工心脏瓣膜经过几代的发展，经临床验证，取得了很好的效果，但还不完善。而新兴的组织工程心脏瓣膜和高分子材料在人工心脏瓣膜领域的应用还处于起步阶段，一定时期内人工心脏瓣膜的需求依旧是机械心脏瓣膜占大多数。本文通过对4代人工机械心脏瓣膜发展和改进的研究，分析了人工机械心脏瓣膜优化设计及制造的几个关键环节。

    【关键词】 机械心脏瓣膜;优化;设计;制造

    【Abstract】 Synthetic heart valve have been developing for several periods and it proves them good effect during the clinical curative，but there are still some faults existing in the application.And on the contrary new emerging technol-ogy of tissue engineering heart valve and macromolecular material applied in the field of synthetic heart valve is still immature.In the predictable future mechanical heart valve would still share most of this market.This article focuses on analysis the key factors during the optimize design and manufacturing of mechanical heart valve through research on the development of four periods of mechanical heart valve.

    【Key words】 mechanical heart valve;optimize;design;manufacture

     1 引言

    心脏瓣膜相当于单向阀门控制血液从心脏流进和流出。如果人的心脏瓣膜不能正常工作，轻则导致日常活动和工作能力的丧失，重则造成死亡。治疗心脏瓣膜疾病的根本方法是通过心脏外科手术安置人工心脏瓣膜。

    人工心脏瓣膜产生至今，经过几代的发展和临床验证，取得了很好的效果。但固有的缺陷依旧存在，即机械瓣膜易致栓，需终生抗凝;生物瓣膜易钙化 ......