【摘要】 目的 探讨癫痫发作敏感大鼠内嗅皮层GFAP免疫反应活性的变化。 方法 用红藻氨酸(KA)10mg/kg(S.C)诱发大鼠出现癫痫发作1个月后，用免疫组化方法观察大鼠内嗅皮层(EC)神经胶质原纤维酸性蛋白(GFAP)免疫反应活性的变化。 结果 发现EC区有大量GFAP免疫反应活性增强。 结论 这一现象可能与动物癫痫敏感性长期增强有关。

    【关键词】 癫痫敏感性;红藻氨酸;神经原纤维酸性蛋白(GFAP)

    The change of glial fibrillary acidi protein immunoreactivity in entorhinal cortex of seizure sensitive rats

    CHENGWei-guo，ZHANG Jian-ping，WANG Bin，et al.

    Department of Neurology，the First Hospital of Wuxi，Wuxi214001，China

    【Abstract】 Objective To study the change of glial fibrillary acidi protein immunoreactivity in entorhinal cortex of seizure sensitive rats.Methods Seizure episodes were induced by administration of kainic acid(10mg/kg s.c)in the Sprague-Dawley rats，one month later.The change of glial fibrillary acidi protein(GFAP)immunoreactivity in en-torhinal cortex(EC)of rats was examined by using immunocytochemical method.Results As compared with control group ......