【摘要】 目的 了解尿路感染病原菌的分布及耐药性，为临床的诊断及合理使用抗生素治疗提供可靠的依据。 方法 对我院2003年1月～2004年9月期间住院及门诊患者尿培养分离出的811株细菌进行鉴定和耐药性分析，特殊耐药株如MRS株、VRE株、HLAR株、产ESBLs细菌的检测均采用K-B法。 结果 尿路感染菌株以大肠埃希菌为主，占31.7%;其次为肠球菌属(17.1%)、凝固酶阴性葡萄球菌(8.0%)、肺炎克雷伯菌(3.9%)以及阴沟肠杆菌、鲍曼不动杆菌、弗劳地枸橼酸杆菌和真菌。产ESBLs细菌的检出率为47.3%;HLAR株为81.3%;VRE株为0.7%;MRS株为84.6%。肠杆菌科细菌除对亚胺培南保持100%敏感外，对其他抗生素耐药率均呈上升趋势;革兰阳性球菌耐药率为普遍较高，仅对万古霉素仍保持较高敏感。 结论 肠杆菌科细菌和肠球菌属细菌分别占尿路感染病原菌的前两位;由于病原菌耐药性呈上升趋势，临床医师应结合尿培养和药敏试验及特殊耐药株的报告结果，合理选用抗生素。

    【关键词】 尿路感染;病原菌;耐药性

    Analysis on the distribution and drug resistance of pathogenic bacteria in urinary tract infection

    LI Bin-bin，DU Xiao-ling.

    Beijing Chaoyang Hospital，Beijing100020，China

    【Abstract】 Objective To provide reliable evidence for diagnosis and treatment of urinary tract infection based on understanding the distribution and drug resistance of pathogenic bacteria.Methods 811strains of bacteria isolated from urine culture of the patients from January2003to September2004were identified and their drug resistances were analyzed.K-B method was used for some special strains ......