【摘要】 目的 探讨斯帕丰(spasfon)在第一产程中促进宫口扩张的作用。方法 采用前瞻性研究方法，对斯帕丰观察组(68例)及安定对照组(68例)进行疗效观察。结果 斯帕丰组及安定组用药至宫口开全时间分别为(138.56±82.15)min及(154.32±139.11)min，用药至分娩时间分别为(182.47±91.96)min及(201.45±146.06)min，两组相比差异均无显著性(P>0.05)；自然分娩率为85.29%(58/68)及69.12%(47/68)，手术产率分别为14.71%(8例剖宫产，2例产钳术/68例)及30.88%(16例剖宫产，5例产钳术/68例)，两组相比差异均有显著性(P<0.05)；两组(手术产指征、胎儿窘迫)中以胎儿窘迫为手术产指征的分别为5例及14例，两组相比差异有显著性(P<0.05)；新生儿窒息和羊水Ⅱ～Ⅲ度污染者两组分别为14.71%(10/68)及23.53%(16/68)，两组相比差异有非常显著性(P<0.01)；两组产后出血量比较分别为，200～350ml 59例及58例，360～450ml 9例及10例，差异均无显著性(P>0.05)。结论 在第一产程中应用斯帕丰松弛和扩张宫颈作用优于安定，且无抑制胎儿呼吸作用，明显减少了剖宫产及产钳术，尤其是减少了新生儿窒息和胎儿宫内窘迫。

    【关键词】 斯帕丰；安定；产程

    Effects of spasfon on course of labor

    SUN Mei-fang,SHI Li-hong,ZOU Wen-yan,et al.

    The Eighth Hospital of Shanghai,Shanghai 200233,China

    【Abstract】 Objective To investigate the effects of spasfon on improving dilatation of cervix in the first stage of labor.Methods Prospective study method was used to observe the curative effect of spasfon group (68 cases) which was observed group and diazepam group (68 cases) which was control group.Results The mean time period from drug administration to full dilation of the cervix was (138.56±82.15)min is spasfon group,and (154.32±139.11)min in diazepam group.The mean time period from drug administration to delivery was(182.47±91.96)min in spason group, and (201.45±146.06)min in control group(P>0.05);Spontaneous delivery rate in spasfon group was 85.29%(58/68), and 69.12%(47/68)in diazepam group.Operative delivery rate was 14.71%(16 cases of cesarean section and 2 cases of obstetric forceps delivery in 68 cases)in spasfon group, and 30.88%(16 cases of cesarean section and 5 cases of obstetric forceps delivery in 68 cases)in diazepam group(P<0.05).There were 5 cases whose indication of operative delivery was fetal distress in spasfon group, and 14 cases in diazepam group(P<0.05).The rate of neonatal asphyxia and Ⅱ～Ⅲ degree pollutional amniotic fluid was 14.71%(10/68)in spasfon group,and 33.82%(16/68)in diazepam group(P<0.01).There were 59 cases in spasfon group and 58 cases in diazepam group whose postpartum blood loss of amount 200～350ml,and 9 cases in spasfon group and 10 cases in diazepam group whose postpartum blood loss of amount 360～450ml(P>0.05).Conclusion The effects of spasfon on improving laxation and dilatation of cervix were better than diazepam in the first stage of labor.While,spasfon had no inhibition to fetal respiration. It cut down the rate of cesarean section and obstetric forceps delivery significantly.More importantly, it cut down the rate of neonatal asphyxia and fetal distress in uterus. ......