【摘要】 目的 观察不同剂量雌激素对L-谷氨酸单钠(MSG)雌性大鼠血脂代谢的影响。方法 选用新生SD雌性大鼠随机分为两组：MSG组和NS组。MSG组于出生后第2，4，6，8，10天皮下注射10% MSG 4g/kg；NS组于皮下注射等体积生理盐水。MSG组于80天龄时再随机分为3个小组，皮下注射不同剂量的苯甲酸雌二醇(EB)。于第10次注射EB后第2天所有组动物均取血，离心分离血清，用酶法测定血脂，并进行相关分析。结果 MSG大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)都明显升高(P<0.01)，高密度脂蛋白胆固醇(HDL-C)显著降低(P<0.01)。雌激素治疗使MSG大鼠TC、TG、LDL-C显著降低，HDL-C显著升高，且雌激素的作用有一定量效关系。结论 雌激素对MSG大鼠升高的TC、TG、LDL-C及降低的HLD-C有治疗作用，且有一定的量效关系。

    【关键词】 SD大鼠；雌激素；血脂；L-谷氨酸单钠

    Effects of different dose of estrogen on the metabolism of serum lipids in MSG rats

    NI Chu-min，HUANG Yi-heng，LIU Hao-yu，et al.

    Guangdong Medical College，Zhanjiang 524023，China

    【Abstract】 Objective To investigate the effects of different dose of estrogen on the metabolism of serum lipids in MSG rats.Methods Newborn Sprague-Dawley(SD) female rat were randomly divided into 2 groups：MSG group and NS group.The MSG group were injected subcutaneously with 10% monosodium L-glutamate (MSG).When the rats were 80 days old ......