大鼠急性坏死性胰腺炎NF-kB的变化及乌司他丁的调控作用
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刘瑞林, 刘牧林, 马良龙,吴 薇
急性坏死性胰腺炎;乌司他丁;NF-kB;肺损伤;IL-6;TNF-a;血清淀粉酶刘瑞林,刘牧林,马良龙,吴薇.大鼠急性胰腺炎NF-kB的变化及乌司他丁的调控作用.世界华人消化杂志2005;13(22)
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刘瑞林, 刘牧林, 吴薇, 蚌埠医学院附属医院胃肠外科 安徽省蚌埠市 233004
马良龙, 淮北市人民医院肝胆外科 安徽省淮北市 235000
通讯作者: 刘瑞林, 233004, 安徽省蚌埠市长淮路41号, 蚌埠医学院附属医院胃肠外科. zyq_lb@yahoo.com.cn
电话: 0552-3064590-2466 传真: 0552-3070260
收稿日期: 2005-08-29 接受日期: 2005-09-17
Effect of ulinastatin on nuclear factor-kBexpression in acute necrotic pancreatitis in rats
Rui-Lin Liu, Mu-Lin Liu, Liang-Long Ma, Wei Wu
Rui-Lin Liu, Mu-Lin Liu, WeiWu, Department of Gastrointestinal Surgery, the Affiliated Hospital ofBengbu Medical College, Bengbu 233004, Anhui Province, China
Liang-Long Ma, Department of Hepatobiliary Surgery, HuaibeiPeople’s Hospital, Huaibei 235000, Anhui Province, China
Correspondence to: Rui-Lin Liu, Department of GastrointestinalSurgery, the Affiliated Hospital of Bengbu Medical College, Bengbu 233004,Anhui Province, China. zyq_lb@yahoo.com.cn
Received: 2005-08-29 Accepted: 2005-09-17
Abstract
AIM:To evaluate the effect of ulinastatin (UTI) on the expression of nuclear factor-kB (NF-kB) and related cytokines in acute necrotic pancreatitis (ANP) in rats.
METHODS:Thirty Sprague-Dawley rats were random-ly divided into sham operation (SO) group, ANP group and UTI treatment group. The levels of NF-kB, interleu-kin-6 (IL-6), tumor necrosis factor-a (TNF-a) and ser-um amylase in rats were detected. ANP model was in-duced by retrograde administration of 50 g/L sodium taurocholate into biliary-pancreatic duct.
RESULTS:In ANP group, the levels of serum amylase (195?907.51±38?618.39 nkat/L), TNF-a (41.37±7.54 ng/L), IL-6 (32.32±8.62 ng/L) as well as the expression of pancreatic and pulmonary NF-kB were all increased as compared with those in SO group (all P <0.01). Aft-er treatment with UTI, the levels of serum amylase (69?804.30±19?432.55 nkat/L), TNF-a (18.66±6.45 ng/L), IL-6 (23.41±7.65 ng/L) as well as the expression of pa-ncreatic and pulmonary NF-kB were all significantly de-creased as compared with those in SO and ANP group (P <0 ......
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