中性粒细胞趋化因子在重症急性胰腺炎中的表达及临床意义
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石建群, 周国雄, 黄介飞, 徐 岷, 张 弘,
重症急性胰腺炎;中性粒细胞趋化因子;发病石建群,周国雄,黄介飞,张弘,魏群.中性粒细胞趋化因子在重症急性胰腺炎中的表达及临床意义.世界华人消化杂志2005;13(22)2704-2707,中性粒细胞趋
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石建群, 周国雄, 黄介飞,徐岷, 张弘, 魏群, 南通大学附属医院消化科江苏省南通市226001226001
南通市社会发展基金资助项目, No.S5054
通讯作者: 周国雄,226001, 剿漳贤ㄊ形魉侣?0号, 南通大学附属医院消化科. zhouguoxiong@pub.nt.jsinfo.net
电话: 0513-5052078
收稿日期: 2005-08-29 接受日期:2005-09-17
Clinical significance andexpression of cytokine-induced neutrophil chemoattractant in severe acutepancreatitis
Jian-Qun Shi, Guo-Xiong Zhou, Jie-Fei Huang, Min Xu, Hong Zhang, Qun Wei
Jian-Qun Shi, Guo-XiongZhou, Jie-Fei Huang, Min Xu, Hong Zhang, Qun Wei, Department ofGastroenterology, the Affiliated Hospital of Nantong University, Nantong226001, Jiangsu Province, China
Supported by Social Development Foundation of Nantong City, No.S5054
Correspondence to: Guo-Xiong Zhou, Department of Gastroenterology,the Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong226001, China. zhouguoxiong@pub.nt.jsinfo.net
Received: 2005-08-29 Accepted: 2005-09-17
Abstract
AIM:To investigate the role of cytokine-induced neutro-philchemoattractant (CINC) in the pathogenesis of severe acute pancreatitis(SAP).
METHODS:The acute pancreatitis model was induced byretrograde injection of 50 g/L sodium taurocholate into thebili-pancreatic duct in SD rats. Forty-eight mas-culinity SD rats wererandomly divided into 2 groups: the sodium taurocholate group and theoperational control group. The serum amylase level and the histol-ogicalpathologic changes of pancreas were measured at different time point ineach group. The expression of pancreatic CINC protein and mRNA weredetermined by immunohistochemistry and semi-quantitative reve-rsetranscriptase polymerase chain reaction (RT-PCR), respectively.
RESULTS:The level of serum amylase in sodium taur-ocholategroup was significantly higher than that in the control group, and itshistological pathologic changes were more significant. The expression ofCINC protein in the pancreatic acinar cells and the expression of CINCmRNA in the pancreatic tissues in the sodium taurocholate group werehigher, and the expression of CINC mRNA in the pancreatic acinar cells inthe sodium taurocholate group were significantly higher (0 ......
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