大肠癌中胃泌素、生长抑素 mRNA 的表达与细胞凋亡及 Bcl-2、Bax 的关系
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茆家定, 吴 佩, 夏祥厚, 胡济群
大肠癌;胃泌素;生长抑素;Bcl-2;Bax,大肠癌中胃泌素、生长抑素mRNA的表达与细胞凋亡及Bcl-2、Bax的关系,茆家定,吴佩,夏祥厚,胡济群,茆家定,通讯作者：,Relationship
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茆家定, 吴佩, 夏祥厚, 胡济群, 皖南医学院弋矶山医院普外科 安徽省芜湖市 241001
茆家定, 男, 1971-02-05生, 安徽省芜湖市人, 汉族, 2003年皖南医学院硕士研究生毕业, 讲师、主治医师, 主要从事胃肠激素与消化道肿瘤的研究.
安徽省自然科学基金资助项目, No. 03043740
安徽省教育厅自然科学基金资助项目, No. 2002Kj307
通讯作者：吴佩, 241001, 安徽省芜湖市赭山西路93号, 皖南医学院弋矶山医院普外科. wp5708@sina.com
电话：0553-5739343
收稿日期：2005-09-10 接受日期：2005-09-30
Relationship between expression of gastrin, somatostatin mRNA and cell apoptosis and Bcl-2, Bax in large intestinal carcinoma
Jia-Ding Mao, Pei Wu, Xiang-Hou Xia, Ji-Qun Hu
Jia-Ding Mao, Pei Wu, Xiang-Hou Xia, Ji-Qun Hu, Department of General Surgery, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China
Supported by Natural Science Foundation of Anhui Province, No. 03043704, and Natural Science Foundation of Education Office of Anhui Province, No. 2002Kj307
Correspondence to: Professor Pei Wu, Department of General Surgery, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China. wp5708@sina.com
Received: 2005-09-10 Accepted: 2005-09-30
Abstract
AIM: To explore the correlations the between expression of somatostatin (SS), gastrin (GAS) mRNA and cell apoptosis index (AI) and Bcl-2, Bax in large intestinal cancer.
METHODS: The expression of GAS and SS genes were detected in 62 colorectal cancer patients by nested reverse transcription polymerase chain reaction (RT-PCR), and the apoptosis of the cells was detected by TUNEL method. The protein expression of,Bcl-2, Bax, GAS, and SS were detected using immunohistochemical staining (S-P method).
RESULTS: The expression of GAS and SS mRNA and protein were basically consistent. The AI in SS high and moderate expression patients with large intestinal cancer was remarkably higher than that in SS low expression ones (q = 5.06, 3.95, both P <0.01), while it was just opposite in GAS positive patients (q = 6 ......
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