【摘要】 目的 探讨血清可溶性细胞表面分化抗原sCD44v6的测定及其临床意义。方法 用酶联免疫吸附试验法(ELISA)检测68例胃肠癌病人血清sCD44v6水平，同时测定35例正常体检病人血清sCD44v6水平作为对照。结果 肠癌组sCD44v6水平(315.67±114.19)ng/ml，胃癌组为(302.53±79.0)ng/ml，两组比较无统计学意义(P>0.05)，但两组皆显著高于正常对照组的(45.6±9.5)ng/ml(P<0.01)。肠癌和胃癌伴转移组sCD44v6水平(421.9±68.09)ng/ml，未转移组(257.68±82.84)ng/ml，转移组显著高于未转移组(P<0.01)。结论 sCD44v6水平与胃肠癌及其转移有明显关联，可作为胃肠癌定性诊断及判断转移的参考指标。

    【关键词】 肿瘤；CD44；酶联免疫吸附试验

    Determination and clinic significance of sCD44v6 in patients with gastrointestinal cancer

    LIU A-lin,ZHOU Min.

    Suchen People’s Hospital of Jiangyan,Taizhou 225512,China

    【Abstract】 Objective To explore the determination and the significance of serum sCD44v6 in patients with gastrointestinal cancer.Methods The concentration of serum sCD44v6 was detected in 68 patients with gastrointestinal cancer by means of enzyme-linked immunosorbent assay. As a control, meanwhile, the sCD44v6 level was also done in 35 healthy persons.Results The concentration of serum sCD44v6 was 315.67±114.19ng/ml in patients with intestinal cancer, and that was 302.53±79.0ng/ml in those with gastric cancer. There was no remarkedly difference of the concentration of serum sCD44v6 between the two groups(P>0.05), but it was significant higher when compared with that of the control group (45.6±9.5ng/ml) (P<0.01). When metastasis occured, the concentration of serum sCD44v6 rose and was markedly higher than that in patients with no metastasis(P<0.01). Conclusion The concentration of serum sCD44v6 was associated with the occurance and metastasis of gastrointestinal cancer. And sCD44v6 may become an important parameter which could indicate the diagnosis and prognosis of gastrointestinal cancer. ......