【摘要】 目的 探讨西咪替丁联合思密达对婴幼儿轮状病毒(RV)腹泻的治疗作用。方法 对2001年11月～2004年11月在我科治疗的大便RV抗原检测阳性的腹泻婴幼儿298例，随机分为2组，治疗组153例，用西咪替丁10～20mg/(kg·d)静滴，加思密达口服，对照组145例，用病毒唑10～15mg/(kg·d)静滴，加止泻药进行对比性研究。结果 治疗组、对照组总有效率分别为95.4%、75.2%(χ2=26.87，P<0.001)，差异有非常显著性，其中发病3天以内者显效达81.2%，总有效率为97.9%；迁延性者显效66.7%，总有效率为90.5%；慢性者显效50%，总有效率为75%。结论 西咪替丁联合思密达治疗婴幼儿轮状病毒腹泻疗效显著，且早期用药可提高疗效，值得临床推广。

    【关键词】 婴幼儿；轮状病毒腹泻；联合治疗

    Clinic observation of cimetidine and smectite combination treatment for rotavirus diarrhea in infants

    HE Rong-li，LIU Cui-hong，FU Rong，et al.

    Department of Pediatrics，Jingzhou Third Hospital,Jingzhou 434001,China

    【Abstract】 Objective To study the effect of cimetidine plus smectite combination treatment for rotavirus diarrhea in infants.Methods During Dec.2001 to Dec.2004,298 patients with rotavirus diarrhea were diagnosed by rotavirus antigen titer in stools, were divided into treatment group (n=153) and control group(n=145).Cimetidine and smectite were given in treatment group, virazole and other antidiarrheic were given in control group.Results In the treatment and control group, overall effectiveness rates were 95.4% and 75.2%, respectively. There were significant differences between the two groups (χ2=26.87,P<0.001). In acute(course<3d), postonent and chronic the diarrhea ......