【摘要】 目的 探讨大豆异黄酮对围绝经期患者血脂代谢的影响。方法 随机抽取妇产科门诊围绝经期女性60例，分为大豆异黄酮组、倍美力组、安慰剂组，分别予大豆异黄酮、倍美力、安慰剂服用3个月，观察药物对血总胆固醇(CHO)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的影响。结果 大豆异黄酮可以明显降低血清CHO、TG、LDL-C、升高HDL-C，与服药前相比差异有显著性，与倍美力组相比无统计学意义，与安慰剂组相比差异有显著性。结论 大豆异黄酮可以明显降低CHO、TG、LDL-C，升高HDL-C，从而降低冠心病的发病率，有望成为HRT良好的替代品，值得深入研究。

    【关键词】 大豆异黄酮；围绝经期；血脂代谢

    Effects of soybean isoflavones on lipids metabolism in the perimenopausal female

    WANG Yu-shuang,ZHANG Guo-rui,LIU Yan-jun,et al.

    Tangshan Hospital of Traditional Chinese Medicine,North China Coal Medical College,Tangshan 063000,China

    【Abstract】 Objective To study the effects of soybean isoflavones on lipids metabolism in the perimenopausal female.Methods 60 patients suffering from the perimenopausal symptoms were randomly divided into 3 groups:the treatment group,the control group and the placebo group.They were administered soybean isoflavones, premarin and placebo respectively for 3 months.The levels of CHO ......