耐药基因__(期刊论文)

乳腺癌ER、PR、CerbB2表达与病理类型相关性研究

http://www.100md.com 《河北北方学院学报(医学版)》 2005年第3期

耐药基因,,乳腺癌;免疫组织化学;ER;PR;CerbB2;,耐药基因,1材料与方法,2结果,3讨论,参考文献

     【摘要】目的：探讨ER、PR与CerbB2在乳腺癌中的表达及相关性。方法：采用免疫组织化学SP法对79例乳腺癌和14例乳腺良性病变进行ER、PR、CerbB2的表达进行检测。结果：乳腺癌中的ER、PR、CerbB2阳性率分别为527%,473%,309%。ER、PR、CerbB2的表达与乳腺癌的组织类型、分化程度具有相关性;ER、PR在所有良性病变、低度恶性肿瘤中表达水平较高，在浸润癌、有淋巴结和全身转移的肿瘤中表达水平较低；CerbB 2在所有良性病变中呈阴性表达，在低度恶性肿瘤中表达水平较低，在浸润癌、有淋巴结和全身转移的肿瘤中表达水平较高；ER、PR与CerbB2、表达之间均存在负相关。结论:ER、PR、CerbB 2的检测对乳腺癌治疗方案的制定和预后估计有重要意义。

    【关键词】乳腺癌;免疫组织化学;ER;PR;CerbB2; 耐药基因

    The Expression of ER 、PR、CerbB2 in Breast Cancerand Study on Their Pathological Relation

    ZHANG Fan, ZHANG Jiuhong,LIU Junchao, et al

    Pathology Department,The First Affiliated Hospital,Hebei North University,Zhangjiakou，075000,China

    【ABSTRACT】 Objective :To study the relationship and expression betwecn ER,PR and C erbB 2 in breast cancer.Methods:The expression of ER, PR , CerbB2 was examined by immunochemistny(sp)in 79 cases with breast cancer and 14 cases with benign illness.Results:The positive rate of E R , PR , C erbB 2 in breast cancer is 527%,473%,309% respectively; 98% 97% and 12% in benign illness respectively.The expression of ER PR and Cerb B 2 is associated with pathological differentiated degrees. The expression of ER、PR in all benign illness and low degree malignat cancer is higher than that of invasive cancer and node matastsis. The expression of CerbB2 is lower in all benign illness 、low degree malignat cancer than that of invasive cancer and node matastsisThere is negative relation between the exptression of ER PR and CerbB2.Conclusion: The expression of ER , PR ,CerbB2 has important significance in treating and prognosis judgement for breast cancer. ......

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