弥散性血管内凝血模型的改进
凝血酶,1材料与方法,2结果,3讨论,参考文献：
摘要：目的 改进弥散性血管内凝血(DIC)的模型。方法 采用凝血酶(100 U/kg×1 h)和氨基己酸(50 mg/kg×1 h)静脉滴注造成家兔急性DIC模型，以凝血酶原时间(PT)、血小板计数(PLT)、纤维蛋白原(FIB)含量和血浆鱼精蛋白副凝固(3P)试验以及肺、肾微血栓形成为观察指标。结果 模型组PT进行性延长、PLT进行性下降、FIB进行性降低、3P试验由阴性转为阳性，且肺、肾病理切片有微血栓形成。结论 采用凝血酶和氨基己酸静脉滴注能够成功地诱发DIC。关 键 词：凝血酶；弥散性血管内凝血；模型
Improvement the model of disseminated intravascular coagulation (DIC)
WANG Yanchun1, Lü Li2
(1.Department of Pharmacology, Jilin Medical and Pharmaceutical College, Jilin City, Jilin Province, 132013;2. Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province, 116023, China)
Abstract:Objective To improve the model of disseminated intravascular coagulation (DIC).Methods DIC was induced by constant iv infusion of thrombin plus PAMBA in rabbits.Platelet count (PLT), PT and fibrinogen (FIB) content plasmaprotamine paracoagulation (3P) test and pathlogical examination of microthrombosis of lungs and kidneys were served as diagnostic indexes of DIC.Results PT in model group was prolonged, PLT and FIB were decreased, 3P test was changed from positive to negative and microthrombosis of lungs and kidneys were formed.Conclusion Iv infusion of thrombin plus PAMBA constant in rabbits can succeed in inducing the DIC. ......
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