正加速度_____正加速度；大鼠；海马；毛细血管

+Gz暴露对大鼠海马毛细血管超微结构的影响

http://www.100md.com 《吉林医药医学学报》 2005年第2期

正加速度,,正加速度；大鼠；海马；毛细血管,1材料和方法,2结果,3讨论,参考文献：

     摘要：目的探讨+Gz重复暴露对大鼠海马毛细血管超微结构的影响。方法 SD大鼠 60只，随机分成对照组、+Gz重复暴露后1 h、6 h、12 h、24 h和48 h组,每组10只。采用动物离心机，建立+Gz引发急性脑缺血模型；常规透射电镜标本制备；对+Gz暴露后不同时间大鼠海马毛细血管超微结构进行观察。结果海马毛细血管超微结构于+Gz重复暴露后1 h开始改变，12 h改变最重，48 h基本恢复正常。结论 +Gz重复暴露导致脑缺血，引起毛细血管超微结构的可逆性损伤。

    关键词：正加速度；大鼠；海马；毛细血管

    Effect of +Gz exposures on rat's hippocampus capillary

    XU Ye, LI Zhixin, TIAN Hongyan，CHEN Moran， ZHU Xinwei, DOU Zhaohua，XIA Yingchun

    (Jilin Medical and Pharmaceutical College：1.Department of Histology and Embryology, 2.Scientific Research Department，Jilin City,Jilin Province,132013；3.Clinic of Santiorium for Outgoing Cadres of Harbin Military Subcommand, Harbin, Heilongjiang Province, 150010, China)

    Abstract:Objective This research observed ultra structure changes of hippocampus capillary after +Gz exposures.Methods Sixty conscious SD rats served as the subjects. They were randomly divided into six groups. By means of an animal centrifuge, we set up a model of acute brain ischemia resulting from +Gz exposures, and use electron microscope to observe the structure of hippocampus capillary at different time after repeated +Gz exposures. Results We found that the ultra structure of capillary started to change at 1 h after +Gz exposures, and it changed most distinctly at 12 h. The structure recovered to normal at 48 h.Conclusion This study demonstrates there is brain ischemia after +Gz exposures, and it induce structure changes of hippocampus capillary, a reversible injury. ......

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