伊曲康唑凝胶剂的体外渗透性及大鼠在体吸收的研究
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李 飞1,于 淼1，马明欣2，王思玲2，苏德森2
(1.沈阳药科大学 高等职业技术学院，辽宁 沈阳 110026； 2.沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要：目的 制备伊曲康唑凝胶剂,并比较其体外渗透性和大鼠在体滞留性。方法 选用卡波姆-940作为基质制备伊曲康唑凝胶剂。采用Franz扩散池进行体外渗透性及大鼠在体滞留性实验。结果 伊曲康唑凝胶体外渗透性很小，而大鼠在体皮肤的累积皮肤滞留量较大，且符合Ritger-Peppas模型。结论 体外渗透性和大鼠在体滞留性试验表明该制剂有利于药物在大鼠皮肤内的滞留。
关键词: 药剂学; 伊曲康唑凝胶剂; 渗透性; 滞留性
中图分类号：R944 文献标识码：A
Study on permeation in vitro and absorption in rats of itraconazole gels
LI Fei1, YU Miao1, MA Ming-xin2, WANG Si-ling2, SU De-sen2
(1.Higher Vocational Technology Collage，Shenyang Pharmaceutical University, Shenyang 110026 China； 2.School of Pharmacy，Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To study the permeation in vitro and absorption in vivo of itraconazole gels. Methods Using carbopol-940 as the base of the gels, the itraconazole gel was prepared. The transdermal permeation tests in vitro were carried by Franz diffusion cell and the absorption was studied in rats. Results The permeability was poor, however, the depot effects of the preparation in skin were great, and the accumulative amounts of ITZ gels fitted Ritger-Peppas kinetic mechanism. Conclusion The permeation is available to the treatment of superficial mycosis
Key words: pharmaceutics；itraconazole gel；permeation；absorption
李 飞1,于 淼1，马明欣2，王思玲2，苏德森2
(1.沈阳药科大学 高等职业技术学院，辽宁 沈阳 110026； 2.沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要：目的 制备伊曲康唑凝胶剂,并比较其体外渗透性和大鼠在体滞留性。方法 选用卡波姆-940作为基质制备伊曲康唑凝胶剂。采用Franz扩散池进行体外渗透性及大鼠在体滞留性实验。结果 伊曲康唑凝胶体外渗透性很小，而大鼠在体皮肤的累积皮肤滞留量较大，且符合Ritger-Peppas模型。结论 体外渗透性和大鼠在体滞留性试验表明该制剂有利于药物在大鼠皮肤内的滞留。
关键词: 药剂学; 伊曲康唑凝胶剂; 渗透性; 滞留性
中图分类号：R944 文献标识码：A
Study on permeation in vitro and absorption in rats of itraconazole gels
LI Fei1, YU Miao1, MA Ming-xin2, WANG Si-ling2, SU De-sen2
(1.Higher Vocational Technology Collage，Shenyang Pharmaceutical University, Shenyang 110026 China； 2.School of Pharmacy，Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To study the permeation in vitro and absorption in vivo of itraconazole gels. Methods Using carbopol-940 as the base of the gels, the itraconazole gel was prepared. The transdermal permeation tests in vitro were carried by Franz diffusion cell and the absorption was studied in rats. Results The permeability was poor, however, the depot effects of the preparation in skin were great, and the accumulative amounts of ITZ gels fitted Ritger-Peppas kinetic mechanism. Conclusion The permeation is available to the treatment of superficial mycosis
Key words: pharmaceutics；itraconazole gel；permeation；absorption
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