HPLC法测定尼莫地平自乳化软胶囊的含量
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孙 辉1 ， 王淑君1 ，王思玲1 ，高福连2
(1.沈阳药科大学 药学院， 辽宁 沈阳 110016 ； 2.沈阳市苏家屯区中心医院，辽宁 沈阳 110101)
摘要：目的 建立高效液相色谱法测定尼莫地平自乳化软胶囊中尼莫地平的含量。方法 采用C18色谱柱，流动相为乙腈– 0.05mol·L-1 NH4Ac (体积比为65:35)，检测波长为360 nm。结果 尼莫地平质量浓度在4.28～32.10 mg·L-1内线性关系良好(r=0.999 6)。平均回收率为99.7%(RSD=0.87%)。结论 该方法可用于尼莫地平自乳化软胶囊中尼莫地平的含量测定。
关键词：药剂学；含量测定；高效液相色谱法；尼莫地平自乳化软胶囊
中图分类号：R94 文献标识码：A
Determination of nimodipine self-emulsifying drug delivery system soft catsule by HPLC
SUN Hui1, WANG Shu-jun 1, WANG Si-ling 1 GAO Fu-liang 2
(1.School of Pharmacy, Shenyang Pharmaceutical University、Shenyang 110016，China; 2. Sujiatun Century Hospital , Shenyang 110101, China)
Abstract: Objective To establish a HPLC method for determination of nimodipine in nimodipine self-emulsifying drug delivery system (NMSEDDS). Methods A C18 column was used with the mobile phase of acetonitrile-0.05mmol.L-1 ammonium acetate (V∶V=65:35) at the detection wavelength of 360nm. Results The calibration curves of nimodipine were linear in the concentration range of 4.28–32.10 mg.L-1 (r=0.999 6). The average recoveries were 99.7%(RSD=0.87%). Conclusion This method can be used for the determination of nimodipine in NMSEDDS.
Key words: pharmaceutics; content determination ; HPLC ;nimodipine self-emulsifying drug delivery system soft capsules
孙 辉1 ， 王淑君1 ，王思玲1 ，高福连2
(1.沈阳药科大学 药学院， 辽宁 沈阳 110016 ； 2.沈阳市苏家屯区中心医院，辽宁 沈阳 110101)
摘要：目的 建立高效液相色谱法测定尼莫地平自乳化软胶囊中尼莫地平的含量。方法 采用C18色谱柱，流动相为乙腈– 0.05mol·L-1 NH4Ac (体积比为65:35)，检测波长为360 nm。结果 尼莫地平质量浓度在4.28～32.10 mg·L-1内线性关系良好(r=0.999 6)。平均回收率为99.7%(RSD=0.87%)。结论 该方法可用于尼莫地平自乳化软胶囊中尼莫地平的含量测定。
关键词：药剂学；含量测定；高效液相色谱法；尼莫地平自乳化软胶囊
中图分类号：R94 文献标识码：A
Determination of nimodipine self-emulsifying drug delivery system soft catsule by HPLC
SUN Hui1, WANG Shu-jun 1, WANG Si-ling 1 GAO Fu-liang 2
(1.School of Pharmacy, Shenyang Pharmaceutical University、Shenyang 110016，China; 2. Sujiatun Century Hospital , Shenyang 110101, China)
Abstract: Objective To establish a HPLC method for determination of nimodipine in nimodipine self-emulsifying drug delivery system (NMSEDDS). Methods A C18 column was used with the mobile phase of acetonitrile-0.05mmol.L-1 ammonium acetate (V∶V=65:35) at the detection wavelength of 360nm. Results The calibration curves of nimodipine were linear in the concentration range of 4.28–32.10 mg.L-1 (r=0.999 6). The average recoveries were 99.7%(RSD=0.87%). Conclusion This method can be used for the determination of nimodipine in NMSEDDS.
Key words: pharmaceutics; content determination ; HPLC ;nimodipine self-emulsifying drug delivery system soft capsules
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