超临界流体技术在纳米药物制剂中的应用
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周丽莉，礼 彤，王立红，王 斓，肖京力
(沈阳药科大学 制药工程学院 ，辽宁 沈阳 110016)
摘要：目的 介绍超临界流体技术在纳米药物制剂中的应用。方法 查阅近10年的文献共30多篇，对超临界流体制备超细微粒技术的特点及其在纳米药物制剂中的应用归纳总结，进行综述。结果与结论 超临界流体制备超细微粒技术具有速度快，产率高，溶剂易彻底除去，无污染等优点。不足之处是：发展时间不长，技术不完善，生产成本高，高压操作。
关键词：药剂学；超临界流体；超细微粒； 药物制剂
中图分类号:R94 文献标识码：A
Application of supercritical fluid technology in pharmaceutical processing
ZHOU Li-li, LI Tong, WANG Li-hong, WANG Lan, XIAO Jing-li
(School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016,China)
Abstract: Objective To introduce the application of supercritical fluid technology in pharmaceutical processing. Methods By summarizing more than 30 articles during the last 10 years, the properties of producing fine particles by supercritical fluid and its application in producing nano pharmaceutical processing were reviewed. Results and Conclusion The technology has advantages of greatly velocity, high yield, residual solvent-free and less pollution. Its disadvantage is short development time, juvenility technology, high cost and high pressure operation.
Key words: pharmaceutics; supercritical fluid; super-microparticle; medicine preparation
周丽莉，礼 彤，王立红，王 斓，肖京力
(沈阳药科大学 制药工程学院 ，辽宁 沈阳 110016)
摘要：目的 介绍超临界流体技术在纳米药物制剂中的应用。方法 查阅近10年的文献共30多篇，对超临界流体制备超细微粒技术的特点及其在纳米药物制剂中的应用归纳总结，进行综述。结果与结论 超临界流体制备超细微粒技术具有速度快，产率高，溶剂易彻底除去，无污染等优点。不足之处是：发展时间不长，技术不完善，生产成本高，高压操作。
关键词：药剂学；超临界流体；超细微粒； 药物制剂
中图分类号:R94 文献标识码：A
Application of supercritical fluid technology in pharmaceutical processing
ZHOU Li-li, LI Tong, WANG Li-hong, WANG Lan, XIAO Jing-li
(School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016,China)
Abstract: Objective To introduce the application of supercritical fluid technology in pharmaceutical processing. Methods By summarizing more than 30 articles during the last 10 years, the properties of producing fine particles by supercritical fluid and its application in producing nano pharmaceutical processing were reviewed. Results and Conclusion The technology has advantages of greatly velocity, high yield, residual solvent-free and less pollution. Its disadvantage is short development time, juvenility technology, high cost and high pressure operation.
Key words: pharmaceutics; supercritical fluid; super-microparticle; medicine preparation
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