肠屏障功能对豚鼠胆囊胆色素结石形成的影响
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苏 洋, 吴硕东, 金俊哲, 张振海, 范 莹
肠屏障功能;胆色素结石;细菌移位;β-葡萄糖醛酸酶,苏洋,吴硕东,金俊哲,张振海,范莹,通讯作者:,电话:,收稿日期:,接受日期:,Influenceofi
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苏洋, 吴硕东, 金俊哲, 张振海, 范莹, 中国医科大学附属二院普外二科 辽宁省沈阳市 110004
苏洋, 男, 1973-12-06生, 辽宁省沈阳市人, 汉族, 博士在读, 主治医师, 主要从事胆道外科疾病研究.
通讯作者: 吴硕东, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属二院普外二科. wusd@cmu2h.com
电话: 024-83955062
收稿日期: 2005-10-25 接受日期: 2005-10-31
Influence of intestinal barrier function on pigment gallstone formation in guinea pig model
Yang Su, Shuo-Dong Wu, Jun-Zhe Jin, Zhen-Hai Zhang, Ying Fan
Yang Su, Shuo-Dong Wu, Jun-Zhe Jin, Zhen-Hai Zhang, Ying Fan, the Second Department of General Surgery, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Shuo-Dong Wu, the Second Department of General Surgery, the Second Affiliated Hospital of China Medical University, Shenyang 110004, China. wusd@cmu2h.com
Received: 2005-10-25 Accepted: 2005-10-31
Abstract
AIM: To investigate the possible action and mechanism of the intestinal barrier function in the pathogenesis of pigment gallstone.
METHODS: Eighty guinea pigs were randomly divided into three groups: normal group (CON), pigment gallstone group (PS) and intestinal mucosa protection group (GLN). Normal forage, pigment gallstone-forming forage and pigment gallstone-forming forage with supplemental intestinal mucosa protector (glutamine) were given to the animals of corresponding groups, respectively. The gallstone-forming rate, morphological changes of intestinal mucosa, intestinal permeability, serum endotoxin and biliary β-glucuronidase were detected after 8 wk.
RESULTS: The gallstone-forming rate was 73.9% in PS. In comparison with those in CON, the intestinal mucosa damage, serum endotoxin level [(1367±525)×10-6 EU/L vs (77±43) ×10-6 EU/L, P < 0.01] and activity of biliary β-glucuronidase (endogenous: from 209.8±47.5 vs 122.1±39.5 Fishman Unit, P < 0.01; exogenous: from 2206.6±983.9 vs 573.5±476.9 Fishman Unit, P < 0 ......
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