灭活的双歧杆菌治疗菌群失调致小鼠肠源性感染
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伦永志, 胡 捷, 李忠朋, 张永轻, 周本正,
双歧杆菌;菌群失调;肠源性感染;血清学;示踪菌,伦永志,刘亚力,胡捷,李忠朋,张永轻,周本正,通讯作者:,电话:,收稿日期:,接受日期:,Applica
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伦永志, 刘亚力, 大连大学医学院辽宁省生物有机化学重点实验室 辽宁省大连市 116622
胡捷, 李忠朋, 张永轻, 周本正, 大连大学医学院 辽宁省大连市 116622
辽宁省教育厅高等学校科研项目资助, No.2023901020
通讯作者: 伦永志, 116622, 辽宁省大连市, 大连大学医学院病原生物学教研室. lunyz@163.com
电话: 0411-87402340
收稿日期: 2005-09-29 接受日期: 2005-10-19
Application of heat-killed bifidobactera in treatment of enterogenic infection caused by dysbacteriosis in mice
Yong-Zhi Lun, Jie Hu, Zhong-Peng Li, Yong-Qing Zhang, Ben-Zheng Zhou, Ya-Li Liu
Yong-Zhi Lun, Ya-Li Liu, Medical College of Dalian University; Key Laboratory of Bio-organic Chemistry of Liaoning Province, Dalian 116622, Liaoning Province, China
Jie Hu, Zhong-Peng Li, Yong-Qing Zhang, Ben-Zheng Zhou, Medical College of Dalian University, Dalian 116622, Liaoning Province, China
Supported by College and University Research Project of Education Ministry of Liaoning Province, No.2023901020
Correspondence to: Yong-Zhi Lun, Department of Pathogenic Biology, Medical College of Dalian University, Dalian 116622, Liaoning Province, China. lunyz@163.com
Received: 2005-09-29 Accepted: 2005-10-19
Abstract
AIM: To observe the curative effect of heat-killed bifi-dobactera on dysbacteriosis-induced enterogenic infe-ction in mice.
METHODS: A total of 40 mice were randomly divided into living bacterium group, heat-killed bacterium group, spontaneous recovery group, and normal control group (10 for each). After treatment with the corresponding methods, the serum indexes such as total protein (TP),albumin (ALB), globulin (GLO), γ-Glutamyl transpepti-dase (GTT), blood urea nitrogen (BUN), lactic dehydro-genase (LDH), creatinine (CER), and tagged bacterium in the homogenate of the mice were detected.
RESULTS: The levels of TP and GLO in the heat-killed bacterium group were significantly increased (71.46±2.01 g/L vs 64.61±2.16 g/L; 35.63±1.57 g/L vs 330.73±1 ......
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