绿茶多酚对实验性酒精性肝损伤大鼠的治疗作用
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周晓蓉, 龚作炯, 袁光金, 张 频
酒精性肝病;茶多酚;EGCG;内毒素血症;细胞因子,周晓蓉,龚作炯,袁光金,张频,周晓蓉,通讯作者:,Effectsofteapolyphenolson
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周晓蓉, 龚作炯, 袁光金, 张频, 武汉大学人民医院感染科 湖北省武汉市 430060
周晓蓉, 女, 1977-06-03生, 湖北黄石人, 汉族, 硕士在读, 主要从事慢性肝病的防治研究.
通讯作者: 周晓蓉, 430060, 湖北省武汉市, 武汉大学人民医院感染科. zhouxiaorong214@yahoo.com.cn
收稿日期: 2005-11-15 接受日期: 2005-12-02
Effects of tea polyphenols on alcoholic liver injury in rats
Xiao-Rong Zhou, Zuo-Jiong Gong, Guang-Jin Yuang, Pin Zhang
Xiao-Rong Zhou, Zuo-Jiong Gong, Guang-Jin Yuang, Pin Zhang, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Correspondence to: Xiao-Rong Zhou, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. zhouxiaorong214@yahoo.com.cn
Received: 2005-11-15 Accepted: 2005-12-02
Abstract
AIM: To investigate the effects of tea polythenols (TP) and epigallocatechin-3-gallate (EGCG) on alcohol-induced liver injury in rats.
METHODS: Forty-eight Sprague-Dawley rats were randomly divided into normal control, model, TP treatment (100, 200 mg/kg), and EGCG treatment (50, 100 mg/kg) groups. Alcoholic liver injury was induced by ethanol plus 0.5 mL fish oil intragastically for 5 wk. Liver injury was assessed by pathological examination and serum alanine aminotransferase (ALT) levels. The plasma endotoxin and serum tumor necrosis factor(TNF)-α, interleukin(IL)-1 and IL-18 levels were measured by enzyme linked immunosorbent assay (ELISA). The expression of CD14, lipopolysaccharide-binding protein (LBP), TNF-α, IL-1 and IL-18 mRNA in the liver were detected by reverse transcription chain reaction (RT-PCR).
RESULTS: Chronic intragastric irrigation of alcohol plus fish oil resulted in the elevated serum ALT, fatty degeneration, focal necrosis and inflammatory cell infiltration in the liver of model rats. These changes were accompanied by increased plasma endotoxin and serum TNF-α, IL-1, IL-18 levels (P < 0.05 or P < 0 ......
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