经肝动脉灌注 GRGDSP 联合化疗栓塞治疗大鼠肝肿瘤的机制
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尹 君, 梁惠民, 钱 骏, 夏 风, 王 勇,
肝癌;GRGDSP;介入性;肝动脉化疗栓塞术,经肝动脉灌注GRGDSP联合化疗栓塞治疗大鼠肝肿瘤的机制,尹君,梁惠民,钱骏,夏风,王勇,邓宪波,王伟,冯敢生,尹君,通讯作者:,Mechanismo
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尹君, 梁惠民, 钱骏, 夏风, 王勇, 邓宪波, 王伟, 冯敢生, 华中科技大学同济医学院附属协和医院放射科 湖北省武汉市 430022
尹君, 男, 1970年生, 河南省信阳市人, 汉族, 2005年华中科技大学同济医学院硕士, 主治医师, 主要从事肿瘤介入治疗研究.
通讯作者: 梁惠民, 430022, 湖北省武汉市, 华中科技大学同济医学院附属协和医院放射科. lianghuimin-email@126.com
电话: 027-62865377
收稿日期: 2005-10-06 接受日期: 2005-10-13
Mechanism of transarterial administration of GRGDSP combined with chemoembolization for treating hepatic carcinoma in rats
Jun Yin, Hui-Min Liang, Jun Qian, Feng Xia, Yong Wang, Xian-Bo Deng, Wei Wang, Gan-Sheng Feng
Jun Yin, Hui-Min Liang, Jun Qian, Feng Xia, Yong Wang, Xian-Bo Deng, Wei Wang, Gan-Sheng Feng, Department of Radiology, the Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Correspondence to: Hui-Min Liang, Department of Radiology, the Affiliated Union Hospital of Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. lianghuimin-email@126.com
Received: 2005-10-06 Accepted: 2005-10-13
Abstract
AIM: To explore the initial mechanisms of trans-arterial administration of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) combined with transarterial chemoembolization (TACE) in the treatment of hepatic carcinoma in Wistar rats.
METHODS: The subcapsular implantation of a solid Walker-256 in the livers was carried out in 30 Wistar rats. The tumor volume V1 was measured using magnetic resonance tomography (MRT) 12 d after the implantation. Then rats were designed into 3 groups. The rats in group A (n = 10) were treated with GRGDSP (250 μg) plus TACE. The rats in group B (n = 10) were only treated with TACE, and the ones in group C were treated with normal saline, serving as the controls. Another 12 d later, MRT were performed again to determine the tumor volume V2 and the value of V2/V1 was calculated. Pathological examination was performed to detect the necrosis and metastasis of carcinoma ......
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