整合素 β1 和固生蛋白 Tenascin 共表达与肝癌浸润转移的关系
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李兴睿, 郭悦青, 易继林
肝细胞癌;固生蛋白;整合素β1;转移,整合素β1和固生蛋白Tenascin共表达与肝癌浸润转移的关系,李兴睿,郭悦青,易继林,通讯作者:,Effectofintegrinβ1andtenascino
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李兴睿, 郭悦青, 易继林, 华中科技大学同济医学院附属同济医院普外科 湖北省武汉市 430030
通讯作者: 李兴睿, 430030, 湖北省武汉市, 华中科技大学同济医学院附属同济医院普外科. lixingrui@sina.com
电话: 027-83663820
收稿日期: 2005-10-17 接受日期: 2005-10-24
Effect of integrin β1 and tenascin on invasion and metastasis of hepatocellular carcinoma
Xing-Rui Li, Yue-Qing Guo, Ji-Lin Yi
Xing-Rui Li, Yue-Qing Guo, Ji-Lin Yi, Department of General Surgery, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Xing-Rui Li, Department of General Surgery, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. lixingrui@sina.com
Received: 2005-10-17 Accepted: 2005-10-24
Abstract
AIM: To explore the expression of Tenascin (TN) and integrinβ1 in hepatocellular carcinoma (HCC) and their effect on the invasion and metastasis of HCC.
METHODS: The expression of TN and integrinβ1 were detected in 42 HCC, 10 hepatic cirrhosis, and 7 normal liver tissues by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical method, respectively. The relations of TN and integrinβ1 expression with the pathological features of HCC were evaluated.
RESULTS: The positive expression of integrinβ1 in HCC tissues was significantly higher than that in non-HCC tissues (c2 = 6.33, P < 0.05). The expression of integrinβ1 in HCC with invasion of tumor envelop(u = 3.06, P < 0.01), Edmondson grades Ⅲ-Ⅳ (u = 3.78, P < 0.01) and non-metastasis (u = 3.65, P < 0.01) was significantly higher than that in HCC with no tumor envelop invasion, Edmondson grades Ⅰ-Ⅱ, and tumor metastasis. The expression of TN in HCC with Edmondson grades Ⅲ-Ⅳ (t = 2.467, P < 0.05), invasion of tumor envelop (t = 2 ......
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