食管鳞癌细胞分化状态对内源性光敏剂 PpIX 产量的影响及对 PDT 的应答
http://www.100md.com
汲振余, 赵立群, 杨观瑞, 薛乐勋, 索振河,
食管癌;细胞分化;光动力学疗法;氨基乙酰丙酸;原卟啉IX,食管鳞癌细胞分化状态对内源性光敏剂PpIX产量的影响及对PDT的应答,汲振余,赵立群,杨观瑞,汲振余,索振河,JahnM.Nesland,彭
 |
| 第2页 |
 |
| 第1页 |
参见附件(478KB，6页)。
汲振余, 赵立群, 杨观瑞, 郑州大学医学院河南省医学科学研究所 河南省郑州市 450052
汲振余, 索振河, Jahn M. Nesland, 彭迁, 挪威国立肿瘤医院肿瘤研究所 奥斯陆 0310 挪威
薛乐勋, 郑州大学医学院分子医学重点实验室 河南省郑州市 450052
汲振余, 男, 1965-08-13生, 山东省莒南县人, 2003年郑州大学博士, 副研究员, 主要从事肿瘤分子生物学研究.
211工程重点建设项目, 教重办No. 2002-2
通讯作者: 杨观瑞, 450052, 河南省郑州市, 郑州大学医学院河南省医学科学研究所. yangguanrui@yahoo.com.cn
电话: 0371-66912679 传真: 0371-66912679
收稿日期: 2005-09-03 接受日期: 2005-09-30
Effects of differentiation of human esophageal cancer cells on 5-aminolevulinic acid-induced endogenous protopophyrin IX production and photodynamic therapy
Zhen-Yu Ji, Li-Qun Zhao, Guan-Rui Yang, Le-Xun Xue, Zhen-He Suo, Jahn M. Nesland, Qian Peng
Zhen-Yu Ji, Li-Qun Zhao, Guan-Rui Yang, Henan Institute of Medical Sciences, Medical College of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zhen-Yu Ji, Zhen-He Suo, Jahn M. Nesland, Qian Peng, the Norwegian Radium Hospital, University of Oslo, Oslo 0310, Norway
Le-Xun Xue, Key Laboratory of Molecular Medicine, Medical College of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Supported by the Key Item in “211 Project”, EMC No. 2002-2
Correspondence to: Dr. Guan-Rui Yang, Institute of Medical Sciences, Medical College of Zhengzhou University, Zhengzhou 450052, Henan Province, China. yangguanrui@yahoo.com.cn
Received: 2005-09-03 Accepted: 2005-09-30
Abstract
AIM: To explore the effects of differentiation on 5-aminolevulinic acid (5-ALA)-derived endogen-ous protopophyrin IX (PpIX) production and photodynamic therapy (PDT) in human esopha-geal cancer.
METHODS: Well differentiated KYSE-450 and poorly differentiated KYSE-70 cell lines were used in this study. Intracellular PpIX production after incubation with various concentrations of ALA was quantified with spectrofluorometry. Moreover, Cell survival after ALA-PDT with different light doses of red light (> 600 nm) and blue light (450 nm) was determined by MTS assay ......
您现在查看是摘要介绍页，详见PDF附件(478KB，6页)。