丹参对重症急性胰腺炎内皮素 -1 mRNA 的影响
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张 莹, 石承先, 黄 平, 任娟娟, 李玉祥
丹参;重症急性胰腺炎;ET-1;大鼠,丹参对重症急性胰腺炎内皮素-1mRNA的影响,张莹,石承先,任娟娟,黄平,李玉祥,张莹,通讯作者:,EffectofSalviaeMiltiorrhizae
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张莹, 石承先, 任娟娟, 贵州省人民医院普通外科 贵州省贵阳市 550000
黄平, 李玉祥, 遵义医学院组胚教研室 贵州省遵义市 563003
张莹, 男, 1974-08-04生, 陕西省铜川市人, 汉族, 2003年第三军医大学肝胆外科博士, 医师, 主要从事肝移植和重症胰腺炎的研究.
贵州省优秀科技教育人才省长基金资助, 黔科教办No.2001-06
通讯作者: 石承先, 550000, 贵州省贵阳市中山东路83号, 贵州省人民医院普通外科. zhangyingdoc@163.com
收稿日期: 2005-9-28 接受日期: 2005-10-19
Effect of Salviae Miltiorrhizae on expression of endothelin-1 mRNA in rats with severe acute pancreatitis
Ying Zhang, Cheng-Xian Shi, Ping Huang, Juan-Juan Ren, Yu-Xiang Li
Ying Zhang, Cheng-Xian Shi, Juan-Juan Ren, Department of General Surgery, Guizhou Provincial People’s Hospital, Guiyang 55000, Guizhou Province, China
Ping Huang, Yu-Xiang Li, Department of Histology and Embryology, Zunyi Medical College, Zunyi 563003, Guizhou Province, China
Supported by the Nomarch Funds for Excellent Science and Technology Teachers of Guizhou Province, No. 2001-06
Correspondence to: Cheng-Xian Shi, Department of General Surgery, Guizhou Provincial People’s Hospital, Guiyang 55000, Guizhou Province, China. zhangyingdoc@163.com
Received: 2005-9-28 Accepted: 2005-10-19
Abstract
AIM: To investigate the expression of endothelin-1 (ET-1) mRNA in severe acute pancreatitis (SAP) as well as the effect of Salviae Miltiorrhizae (SM) on ET-1 mRNA expression in rats.
METHODS: Forty-five Wistar rats were randomly divided into 3 groups: model group (MG, n = 15), SM group (SMG, n = 15), and control group (CG, n = 15). Severe acute pancreatitis was induced by intraductal injection of 50 g/L sodium taurocholate (1.0 mL/kg) in MG and SMG. The rats in SMG were then treated with Salviae Miltiorrhizae [2 mL/(kg•d)]. Sham-operation was only performed in CG. The levels of ascites, serum ET-1 and amylase (AMY) were determined at 24 h. The expression of ET-1 mRNA was examined by in situ hybridization in pancreatic tissues. The pathological changes of the pancreas were observed 24 h after modeling ......
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