肠三叶因子对内毒素诱导幼鼠肠组织NO和MDA的作用
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李 军, 赵亚娟, 孙 梅, 潘莉莉, 高 红
肠;内毒素;肠三叶因子;一氧化氮;丙二醛,李军,赵亚娟,孙梅,潘莉莉,高红,李军,通讯作者:,Effectsofrecombinantinte
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李军, 赵亚娟, 孙梅, 中国医科大学第二临床学院儿科 辽宁省沈阳市 110004
潘莉莉, 中国医科大学第二临床学院中心实验室 辽宁省沈阳市 110004
高红, 卫生部小儿先天畸形重点实验室，中国医科大学第二临床学院小儿外科 辽宁省沈阳市 110004
李军, 女, 1968-04生, 天津市人, 汉族, 2001年中国医科大学硕士, 副教授, 主要从事小儿消化系统疾病的研究.
通讯作者: 孙梅，110004，辽宁省沈阳市和平区三好街36号，中国医科大学第二临床学院儿科. sunm@cmu2h.com
电话: 024-83956503 传真：024-83955509
收稿日期: 2005-10-25 接受日期: 2005-10-31
Effects of recombinant intestinal trefoil factor on endotoxin-induced expression of nitric oxide and malondialdehyde in intestinal tissues of infant rats
Jun Li, Ya-Juan Zhao, Mei Sun, Li-Li Pan, Hong Gao
Jun Li, Ya-Juan Zhao, Mei Sun, Department of Pediatrics, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Li-Li Pan, Central Laboratory, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Hong Gao, Key Laboratory of Health Ministry for Congenital Malformations, Department of Pediatric Surgery, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Mei Sun, Department of Pediatrics, the Second Affiliated Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. sunm@cmu2h.com
Received: 2005-10-25 Accepted: 2005-10-31
Abstract
AIM: To investigate the effects of recombinant intestinal trefoil factor (rITF) on the expression of nitric oxide (NO) and malondialdehyde (MDA) induced by lipopolysaccharide (LPS) in infant rats.
METHODS: Ninety-six 10-day-old Wistar rats were divided into 3 groups. The rats in group A served as normal controls and were injected with normal saline (1 mL/kg) intraperioneally. The rats in group B and C were intraperioneally treated with LPS (1 mL/kg) and LPS (1 mL/kg) plus rITF (5 g/L, 0.1 mL), respectively ......
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