肝癌组织中脱-γ-羧基凝血酶原的测定及意义
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袁联文, 唐 伟, 周建平, 幕内雅敏
肝癌;脱-γ-羧基凝血酶原;电化学发光免疫分析法,袁联文,周建平,唐伟,幕内雅敏,袁联文,通讯作者:,Quantitativemeasuremento
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袁联文, 周建平, 中南大学湘雅二医院老年外科 湖南省长沙市 410011
唐伟, 幕内雅敏, 日本东京大学附属病院肝胆胰外科 日本东京 113-8655
袁联文, 男, 1971-10-23生, 湖南祁阳人, 汉族, 2003年中南大学湘雅医学院博士, 副教授, 主要从事消化道肿瘤研究.
通讯作者: 袁联文, 410011, 湖南省长沙市人民中路86号,中南大学湘雅二医院老年外科. yuanlianwen1971@yahoo.com.cn.
电话: 0731-4129801
收稿日期: 2005-10-25 接受日期: 2005-10-28
Quantitative measurement of des-γ-carboxy-prothrombin in cancerous and non-cancerous liver tissue and its role in hepatocellular carcinoma
Lian-Wen Yuan, Wei Tang, Jiang-Ping Zhou, Masatoshi Makuuchi
Lian-Wen Yuan, Jiang-Ping Zhou, Department of Geriatrics Surgery, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Wei Tang, Masatoshi Makuuchi, Department of Hepatobiliary and Pancreatic Surgery, the Affiliated Hospital, University of Tokyo, Tokyo 113-8655, Japan
Correspondence to: Dr. Lian-Wen Yuan, Department of Geriatrics Surgery, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China. yuanlianwen1971@yahoo.com.cn
Received: 2005-10-25 Accepted: 2005-10-28
Abstract
AIM: To measure the levels of des-γ-carboxy-prothrombin(DCP)in cancerous and non-cancer-ous liver tissues of hepatocellular carcinoma (HCC)quantitatively, and to investigate their roles in the elevated serum DCP and clinical significance.
METHODS: The levels of DCP in serum, cancerous and non-cancerous liver tissue samples prepared from 41 patients with a single HCC nodule were measured using an electro-chemiluminescence immunoassay (ECLIA).
RESULTS: The levels of DCP in HCC tissues ranged from 7.1 to 2098623.7 mAU/g tissue weight, with a median of 84447.7 mAU/g, and the levels of DCP in non-cancer tissues ranged from 0 to 23299.2 mAU/g tissue weight, with a median of 888.1 mAU/g. The DCP levels in HCC tissue were significantly higher than those in non-cancer tissue (4 925 ......
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