大肠癌中 IGF-2 蛋白的表达及相关性研究
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段琼红, 吕美霞, 卢祖洵, 聂绍发
大肠肿瘤;胰岛素样生长因子-2;c-Myc;Survivin;免疫组织化学,大肠癌中IGF-2蛋白的表达及相关性研究,段琼红,吕美霞,聂绍发,卢祖洵,通讯作者:,Expressionandsign
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段琼红, 吕美霞, 聂绍发, 华中科技大学同济医学院流行病与卫生统计学系 湖北省武汉市 430030
卢祖洵, 华中科技大学同济医学院社会医学系 湖北省武汉市 430030
国家自然科学基金资助项目, No.30371239
通讯作者: 聂绍发, 430030, 武汉市航空路13号, 华中科技大学同济医学院流行病与卫生统计学系. sf_nie@mails.tjmu.edu.cn
电话: 027-83693763
收稿日期: 2005-10-25 接受日期: 2005-10-31
Expression and significance of insulin-1ike growth factor 2 protein in colorectal cancer
Qiong-Hong Duan, Mei-Xia Lv, Zu-Xun Lu, Shao-Fa Nie
Qiong-Hong Duan, Mei-Xia Lv, Shao-Fa Nie, Department of Epidemiology and Health Statistics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Zu-Xun Lu, Department of Community Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Supported by National Natural Science Foundation of China, No.30371239
Correspondence to: Professor Shao-Fa Nie, Department of Epidemiology and Health Statistics, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, Hubei Province,China. sf_nie@mails.tjmu.edu.cn
Received: 2005-10-25 Accepted: 2005-10-31
Abstract
AIM: To explore the correlation of the expression of insulin-1ike growth factor 2 (IGF-2), Survivin, and c-Myc protein in colorectal cancer, and to clarify the role of IGF-2 in the occurrence and progression of colorectal cancer.
METHODS: The single and associated expression of IGF-2, Survivin, and c-Myc protein was detected by immunohistochemical SP method in the tissues of colorectal cancer and the marge of the excision part of the tumor.
RESULTS: The positive rate of IGF-2 was 27.3% in the cancer tissue, and 5.0% in the marge tissue. There was significant difference between them (P < 0.05). The positive expression of IGF-2 was significantly related with Duke’s staging (A-B: 16.67% vs C-D: 83 ......
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